Purifen 300 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Dexibuprofen |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Relief of signs and symptoms of osteoarthritis
- Rheumatoidal disorders treatment
- Acute symptomatic treatment of painful menstruation
- Symptomatic treatment of mild to moderate pain
- Adjuvant with common cold and influenza associated with headache
Pharmacology
Dexibuprofen is the pharmacologically active enantiomer of racemic ibuprofen with analgesic and anti-inflammatory action; it is absorbed primarily from the small intestine and metabolized in the liver, with an elimination half-life of 1.8-3.5 hours.
Dosage & Administration
Recommended dosage is 600-900 mg per day, at 2-3 divided doses, temporary increase to 1200 mg per day is permissible in acute disorders
Drug Interactions
- Anticoagulant
- Hydantoine and sulfonamide
- Ticlopidine
- Lithium
- Other NSAIDs
- ACE inhibitors
- Beta blockers
- Cyclosporine
- Tacrolimus
- Corticosteroids
- Digoxin
- Methotrexate
- Pentoxyfiline
- Phenytoine
- Probenecid
- Sulfinpyrazon
- Sulfonylurea
- Thiazide and thiazide type diuretics
- Zidovudine
Contraindications
- Hypersensitivity to Dexibuprofen
- Previous history of hypersensitivity to NSAIDs
- Active or suspected hemorrhage
- Serious heart diseases
- Kidney function impairment (GFR <30ml/min)
- Liver function impairment
Side Effects
- Dyspepsia
- Diarrhea
- Fatigue
- Headache
- Nausea
- Vomiting
- Abdominal pain
- Hypersensitivity reactions
- Bleeding
- Ulcer
Pregnancy & Lactation
- Avoid use during pregnancy due to potential teratogenic impact
- Use with caution in nursing mothers
Precautions & Warnings
Use with caution in patients with bronchial asthma, hepatic, renal or cardiac insufficiency, hypertension, systemic lupus, or other autoimmunological disease
Use in Special Populations
- Hepatic Impairment: Start with low amounts and closely monitor
- Renal Impairment: Start amount must be reduced in mild to moderate impairments
- Children Dose: Not licensed for use in children under 18 years of age in the UK; in some countries, it has been given to children aged 6 years and over
- Elderly People: Lowest effective dose recommended
Overdose Effects
Symptomatic treatment is recommended; activated charcoal and induced vomiting may be necessary in severe cases
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
Do not store above 30°C; keep away from light and out of the reach of children