A-Fenac SR 100 mg (Tablet (Sustained Release))

Indications

• Inflammatory and degenerative forms of rheumatism
• Chronic involutive
• Polyarthritis
• Ankylosing spondylarthritis
• Osteoarthritis
• Spondylarthroses
• Acute gout
• Peri-articular rheumatic disorders
• Sprain
• Bruises
• Dislocations
• Fractures
• Soft tissue injuries
• Surgical interventions
• Primary dysmenorrhoea
• Episiotomy
• Adnexitis
• Endometritis
• Parametritis
• Salpingitis
• Mastitis
• Pre-operative medication for the prevention of pain, inflammation, and swelling
• Post-operative and post-traumatic pain, inflammation, and swelling
• Prevention of pain and treatment of inflammation and swelling of patients operated in the urogenital tract
• Renal and biliary colic

Pharmacology

• Non-steroidal anti-inflammatory drug (NSAID)
• Anti-rheumatic
• Analgesic
• Antipyretic
• Uricosuric effect
• Inhibits prostaglandin biosynthesis
• Rapid and complete absorption from the gastrointestinal tract
• Metabolized in the liver
• Undergoes first pass metabolism

Dosage & Administration

• 75-150 mg daily in 2 to 3 divided doses for adults
• Dose reduction in long term use
• Recommended dosage for Diclofenac FC Tablet, SR Tablet, Dispersible Tablet, TR Capsule, Suppository, injection, and Gel
• Maximum daily doses for various formulations
• Specific dosage for children and elderly patients

Interaction

• Potential drug interactions with lithium and digoxin
• Increased risk of haemorrhage with anticoagulants
• Safe use with oral antidiabetic agents
• Potential nephrotoxicity with cyclosporin
• Cases of serious toxicity with methotrexate and NSAIDs
• Potential convulsions with quinolone antimicrobials
• Caution with concomitant therapy of NSAID and quinolones
• Potential increase in unwanted effects with other NSAIDs and steroids

Contraindications

• Hypersensitivity to any ingredient
• Peptic ulcer
• Hypersensitivity to Diclofenac or other non-steroid anti-inflammatory agents
• Contra-indicated in asthmatic patients

Side Effects

• Mild, rare, and transient adverse effects
• Epigastric pain
• Eructation
• Nausea
• Diarrhea
• Dizziness
• Headache
• Peripheral edema
• Skin reactions such as rash and eczema
• Local irritation and reddening of the skin with A-Fenac SR Gel

Pregnancy & Lactation

• Use only for compelling reasons during pregnancy
• Lowest effective dose should be used
• Not recommended during the first trimester
• Not recommended during lactation

Precautions & Warnings

• Close observation for peptic ulceration or gastrointestinal bleeding
• Close observation for patients with advanced age
• Avoid contact with eyes or mucous membranes
• Avoid oral consumption

Therapeutic Class

• Drugs for Osteoarthritis
• Drugs used for Rheumatoid Arthritis
• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

• Store in a cool and dry place
• Protected from light
• Store below 30°C
• Keep out of the reach of children

Related Brands

• A-Fenac 25 mg (Tablet) - acme-laboratories-ltd
• A-Fenac 50 mg (Tablet) - acme-laboratories-ltd