Precinol 50 mg (Tablet)
Unit Price: ৳ 0.73 (100's pack: ৳ 73.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Atenolol |
| Company | Doctors chemical works ltd |
Indications
- Management of hypertension
- Long-term management of angina pectoris
- Management of hemodynamically stable patients with acute myocardial infarction
Pharmacology
- β1 selective (cardioselective) β-adrenergic receptor antagonist
- Hydrophilic nature
- Poor penetration of lipid cell membranes
Dosage & Administration
- Initial dose of 50 mg for hypertension
- Initial dose of 50 mg for angina pectoris
- Intravenous administration for acute myocardial infarction
Interactions
- Catecholamine-depleting drugs additive effect
- Additive effect with calcium channel blockers
- Potential adverse effects with disopyramide and amiodarone
- Exacerbation of rebound hypertension with clonidine withdrawal
- Decrease in hypotensive effects with prostaglandin synthase inhibiting drugs
- Increased risk of severe allergic reaction with beta blockers
- Risk of bradycardia when used concomitantly with digitalis glycosides
Contraindications
- Sinus bradycardia
- Heart block greater than first degree
- Cardiogenic shock
- Overt cardiac failure
- Hypersensitivity to atenolol or any of the drug product’s components
Side Effects
- Agranulocytosis
- Allergic reactions
- Reversible mental depression
- Mesenteric arterial thrombosis
- Skin rashes and dry eyes
- Erythematous rash
Pregnancy & Lactation
- Pregnancy Category D
- Caution in nursing women
- Risk of bradycardia in breast-fed infants
- Higher likelihood of adverse effects in premature or impaired renal function infants
Precautions & Warnings
- Evaluation of patients already on beta blockers before administering
- Aggravation of peripheral arterial circulatory disorders
- Caution in impaired renal function
- Cautious dose selection for elderly patients
- Assessment of renal function in hypertensive or myocardial infarction patients
- Dosage adjustment for patients with severe renal impairment
Use in Special Populations
- Dosage adjustment for elderly or renal impaired patients
- Maximum recommended dosages based on renal function
- Lower starting dose for some renal impaired or elderly hypertension patients
- Caution in hemodialysis patients
Overdose Effects
- Reported symptoms of lethargy, respiratory disorders, bradycardia
- Common effects of beta-adrenergic blocking agent overdose
- Treatment with induced emesis, gastric lavage, activated charcoal, or hemodialysis as necessary
Therapeutic Class
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Expiry date adherence
- Keep out of reach of children
- Dispensation only on the prescription of a registered physician