Clofenac SR 100 mg (Tablet (Sustained Release))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)

Strip Price: ৳ 50.00

Medicine Details

Category	Details
Generic	Diclofenac sodium
Company	Square pharmaceuticals plc
Also available as	Clofenac 50 mg tablet Clofenac 125 mg suppository Clofenac 25 mg suppository Clofenac 50 mg suppository Clofenac 1 w gel Clofenac dt 465 mg tablet

Therapeutic class

Drugs for Osteoarthritis
Drugs used for Rheumatoid Arthritis
Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Indications

Inflammatory and degenerative forms of rheumatism
Chronic involutive
Polyarthritis
Ankylosing spondylarthritis
Osteoarthritis
Spondylarthroses
Acute gout
Peri-articular rheumatic disorders
Sprain
Bruises
Dislocations
Fractures
Soft tissue injuries
Surgical interventions
Primary dysmenorrhoea
Episiotomy
Adnexitis
Endometritis
Parametritis
Salpingitis
Mastitis
Pre-operative medication for the prevention of pain, inflammation, and swelling
Post-operative and post-traumatic pain, inflammation, and swelling
Prevention of pain and treatment of inflammation and swelling of patients operated in the urogenital tract, renal and biliary colic

Pharmacology

Potent non-steroidal anti-inflammatory drug (NSAID) with pronounced anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties. It has some uricosuric effect. Rapid and complete absorption from the gastro-intestinal tract. Metabolized in the liver and undergoes first-pass metabolism.

Dosage and administration

Diclofenac fc tablet:
- Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food. Dose should be reduced in long term use.
Diclofenac sr tablet:
- Adult: 1 tablet daily, taken whole with liquid, preferably at meal times. If necessary, the daily dose can be increased to 150 mg by supplementation with conventional tablets.
- Children: 1-3 mg of diclofenac/kg body weight daily in divided doses.
- Elderly patients: The lowest effective dosage is recommended.
Diclofenac dispersible tablet:
- Adults:
  - Recommended daily dosage is 2-3 tablets and the maximum daily dose is 150 mg.
- Children: 1-3 mg/kg body weight. To be dropped into a half-glass of water and the liquid is to be stirred to aid dispersion before swallowing.
Diclofenac tr capsule: One capsule daily, preferably after mealtimes.
Diclofenac suppository: For adults: 50 mg suppository 2-3 times daily. Maximum daily dose is 150 mg.
Diclofenac injection: Usual dose for adults is 1 ampoule daily. In serious cases this dose may be increased up to 2 ampoules daily.
Diclofenac gel: For external use only. Apply 2-4 g to the skin 3-4 times daily, rubbed in lightly. Can be used in addition to further treatment with other dosage forms.

Interaction

Lithium and digoxin: May increase plasma concentrations.
Anticoagulants: Isolated reports of an increased risk of haemorrhage.
Antidiabetic agents: Can be given together with oral antidiabetic agents without influencing their clinical effect.
Cyclosporin: Cases of nephrotoxicity reported in patients receiving cyclosporin and diclofenac concomitantly.
Methotrexate: Cases of serious toxicity reported when methotrexate and NSAIDs are given within 24 hours of each other.
Quinolone antimicrobials: Caution should be exercised when considering concomitant therapy of NSAID and quinolones.
Other nsaids and steroids: Co-administration of diclofenac with other systemic NSAIDs and steroids may increase the frequency of unwanted effects.

Contraindications

Hypersensitive to any ingredient of the products
Peptic ulcer
Hypersensitivity to Diclofenac or other non-steroid anti-inflammatory agents
Contra-indicated in asthmatic patient in whom attack with asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor
Not to be used under occlusive airtight dressings.

Side effects

Mild, rare and transient adverse effects
Epigastric pain
Eructation
Nausea
Diarrhea
Dizziness
Headache
Peripheral edema
Skin reactions such as rash and eczema
Local irritation and reddening of the skin
Skin rash

Pregnancy and lactation

Should be employed only for compelling reasons during pregnancy
The lowest effective dose should be used
Not recommended during the first trimester of pregnancy
Not recommended during lactation
A very insignificant quantity may be detected in breast milk but no undesirable effects on the infant to be expected.

Precautions and warnings

In rare instances where peptic ulceration or gastrointestinal bleeding occurs, close observation is required
Keep away from eyes and mucus membranes
Hands should be washed properly after application
Not to be taken by mouth

Storage conditions

Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children.