Clofenac SR 100 mg (Tablet (Sustained Release))
Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Diclofenac sodium |
| Company | Square pharmaceuticals plc |
| Also available as |
Therapeutic class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Indications
- Inflammatory and degenerative forms of rheumatism
- Chronic involutive
- Polyarthritis
- Ankylosing spondylarthritis
- Osteoarthritis
- Spondylarthroses
- Acute gout
- Peri-articular rheumatic disorders
- Sprain
- Bruises
- Dislocations
- Fractures
- Soft tissue injuries
- Surgical interventions
- Primary dysmenorrhoea
- Episiotomy
- Adnexitis
- Endometritis
- Parametritis
- Salpingitis
- Mastitis
- Pre-operative medication for the prevention of pain, inflammation, and swelling
- Post-operative and post-traumatic pain, inflammation, and swelling
- Prevention of pain and treatment of inflammation and swelling of patients operated in the urogenital tract, renal and biliary colic
Pharmacology
Potent non-steroidal anti-inflammatory drug (NSAID) with pronounced anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties. It has some uricosuric effect. Rapid and complete absorption from the gastro-intestinal tract. Metabolized in the liver and undergoes first-pass metabolism.
Dosage and administration
- Diclofenac fc tablet:
- Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food. Dose should be reduced in long term use.
- Diclofenac sr tablet:
- Adult: 1 tablet daily, taken whole with liquid, preferably at meal times. If necessary, the daily dose can be increased to 150 mg by supplementation with conventional tablets.
- Children: 1-3 mg of diclofenac/kg body weight daily in divided doses.
- Elderly patients: The lowest effective dosage is recommended.
- Diclofenac dispersible tablet:
- Adults:
- Recommended daily dosage is 2-3 tablets and the maximum daily dose is 150 mg.
- Children: 1-3 mg/kg body weight. To be dropped into a half-glass of water and the liquid is to be stirred to aid dispersion before swallowing.
- Adults:
- Diclofenac tr capsule: One capsule daily, preferably after mealtimes.
- Diclofenac suppository: For adults: 50 mg suppository 2-3 times daily. Maximum daily dose is 150 mg.
- Diclofenac injection: Usual dose for adults is 1 ampoule daily. In serious cases this dose may be increased up to 2 ampoules daily.
- Diclofenac gel: For external use only. Apply 2-4 g to the skin 3-4 times daily, rubbed in lightly. Can be used in addition to further treatment with other dosage forms.
Interaction
- Lithium and digoxin: May increase plasma concentrations.
- Anticoagulants: Isolated reports of an increased risk of haemorrhage.
- Antidiabetic agents: Can be given together with oral antidiabetic agents without influencing their clinical effect.
- Cyclosporin: Cases of nephrotoxicity reported in patients receiving cyclosporin and diclofenac concomitantly.
- Methotrexate: Cases of serious toxicity reported when methotrexate and NSAIDs are given within 24 hours of each other.
- Quinolone antimicrobials: Caution should be exercised when considering concomitant therapy of NSAID and quinolones.
- Other nsaids and steroids: Co-administration of diclofenac with other systemic NSAIDs and steroids may increase the frequency of unwanted effects.
Contraindications
- Hypersensitive to any ingredient of the products
- Peptic ulcer
- Hypersensitivity to Diclofenac or other non-steroid anti-inflammatory agents
- Contra-indicated in asthmatic patient in whom attack with asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor
- Not to be used under occlusive airtight dressings.
Side effects
- Mild, rare and transient adverse effects
- Epigastric pain
- Eructation
- Nausea
- Diarrhea
- Dizziness
- Headache
- Peripheral edema
- Skin reactions such as rash and eczema
- Local irritation and reddening of the skin
- Skin rash
Pregnancy and lactation
- Should be employed only for compelling reasons during pregnancy
- The lowest effective dose should be used
- Not recommended during the first trimester of pregnancy
- Not recommended during lactation
- A very insignificant quantity may be detected in breast milk but no undesirable effects on the infant to be expected.
Precautions and warnings
- In rare instances where peptic ulceration or gastrointestinal bleeding occurs, close observation is required
- Keep away from eyes and mucus membranes
- Hands should be washed properly after application
- Not to be taken by mouth
Storage conditions
Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children.