Clofenac 25 mg (Suppository)
Unit Price: ৳ 16.00 (3 x 5: ৳ 240.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diclofenac sodium |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Inflammatory and degenerative forms of rheumatism
- Chronic involutive
- Polyarthritis
- Ankylosing spondylarthritis
- Osteoarthritis
- Acute gout
- Peri-articular rheumatic disorders
- Sprain
- Bruises
- Dislocations
- Fractures
- Soft tissue injuries
- Surgical interventions
- Primary dysmenorrhoea
- Episiotomy
- Adnexitis
- Endometritis
- Parametritis
- Salpingitis
- Mastitis
- Pre-operative medication for the prevention of pain, inflammation, and swelling
- Post-operative and post-traumatic pain, inflammation, and swelling
- For the prevention of pain and treatment of inflammation and swelling of patients operated in the urogenital tract
- Renal and biliary colic
Pharmacology
- Potent non-steroidal anti-inflammatory drug (NSAID)
- Pronounced anti-rheumatic
- Anti-inflammatory
- Analgesic
- Antipyretic properties
- Uricosuric effect
- Inhibits prostaglandin biosynthesis
- Rapid and complete absorption from the gastro-intestinal tract
- Metabolized in the liver
- Undergoes first pass metabolism
Dosage & Administration
- Diclofenac FC Tablet: Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food. Dose should be reduced in long term use
- Diclofenac SR Tablet: Adult: 1 tablet daily, taken whole with liquid, preferably at meal times
- Diclofenac Dispersible Tablet: Adults: The recommended daily dosage is 2-3 tablets and the maximum daily dose is 150 mg. In milder cases, 2 tablets of Diclofenac DT per day are sufficient
- Diclofenac TR Capsule: One capsule daily
- Diclofenac Suppository: For adults: 50 mg suppository 2-3 times daily. Maximum daily dose is 150 mg
- Diclofenac injection: For adults the usual dose is 1 ampoule daily. In serious cases this dose may be increased up to 2 ampoules daily
- Diclofenac Gel: For external use only. Depending on the size of area to be treated, 2-4 g of Diclofenac gel should be applied to the skin 3-4 times daily
Interaction
- Lithium and digoxin: Clofenac may increase plasma concentrations of lithium and digoxin
- Anticoagulants: Increased risk of haemorrhage
- Antidiabetic agents: Can be given together with oral antidiabetic agents without influencing their clinical effect
- Cyclosporin: Cases of nephrotoxicity reported in patients receiving cyclosporin and diclofenac concomitantly
- Methotrexate: Cases of serious toxicity reported when methotrexate and NSAIDs are given within 24 hours of each other
- Quinolone antimicrobials: Caution should be exercised when considering concomitant therapy of NSAID and quinolones
- Other NSAIDs and steroids: Co-administration may increase the frequency of unwanted effects
Contraindications
- Hypersensitive to any ingredient of the products
- Peptic ulcer
- Hypersensitivity to Diclofenac
- Contra-indicated in asthmatic patient in whom attack with asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor
Side Effects
- Mild, rare, and transient adverse effects
- Epigastric pain
- Eructation
- Nausea
- Diarrhea
- Dizziness
- Headache
- Peripheral edema
- Skin reactions such as rash and eczema
- Local irritation and reddening of the skin
- Skin rash
Pregnancy & Lactation
- Should be employed only for compelling reasons during pregnancy
- Lowest effective dose should be used
- Not recommended during the first trimester of pregnancy
- Not recommended during lactation due to insufficient clinical data
Precautions & Warnings
- Close observation in patients with peptic ulceration or gastrointestinal bleeding
- Avoid contact with eyes or mucus membranes
- Should not be taken by mouth
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Store in a cool and dry place
- Protected from light
- Store below 30°C
- Keep out of the reach of children