Diclofen Plus (75 mg+20 mg)/2 ml (IM Injection)

2 ml ampoule: ৳ 15.10 (5 x 3: ৳ 226.50)

Medicine Details

Category Details
Generic Diclofenac sodium lidocaine hydrochloride
Company Opsonin pharma ltd

Indications

  • Relief of pain and inflammation
  • Treats arthritic conditions
  • Treats musculoskeletal disorders
  • Treats periarthritis, tendinitis, tenosynovitis, bursitis
  • Manages pain resulting from trauma
  • Postoperative pain management
  • Relieves pain of renal colic
  • Minimizes pain at the injection site

Pharmacology

  • Potent nonsteroidal antiinflammatory drug (NSAID)
  • Marked analgesic and antipyretic properties
  • Inhibits prostaglandin synthesis
  • Peak plasma concentration achieved within half an hour

Dosage & Administration

  • Adult dosage: one ampoule once or twice daily by intramuscular injection
  • Renal colic dosage: one ampoule once daily intramuscularly, second dose after 30 minutes if necessary
  • Children's dosage for juvenile chronic arthritis
  • Dosage recommendation for elderly patients

Interaction

  • Increases plasma concentrations of Lithium and Digoxin
  • Isolated reports of increased risk of hemorrhage with anticoagulant therapy
  • Can be given together with oral antidiabetic agents
  • Possible nephrotoxicity when combined with Cyclosporin
  • Serious toxicity reported with concomitant use of Methotrexate and NSAIDs
  • Potential interaction with quinolone antimicrobials leading to convulsions
  • Possible increase in unwanted effects with co-administration of other NSAIDs and steroids
  • Inhibition of diuretics activity
  • Possible increase in serum potassium levels with potassium-sparing diuretics

Contraindications

  • Hypersensitivity to Diclofenac
  • Active or suspected peptic ulcer or gastrointestinal bleeding
  • Previous attacks of asthma, urticaria or acute rhinitis
  • Hypersensitivity to local anaesthetics of the amide type
  • Adams-Stokes syndrome or severe degrees of heart block
  • Hypersensitivity to excipients used in the formulation

Side Effects

  • Mild and transient side effects
  • Gastrointestinal discomfort, nausea, diarrhea, bleeding
  • Injection site disorder, abscesses, local necrosis
  • CNS reactions such as drowsiness, dizziness, disorientation, confusion

Pregnancy & Lactation

  • Not recommended unless compelling reasons exist
  • Lowest effective dosage should be used
  • Not recommended during the last trimester
  • Small quantities may be detected in breast milk with no expected undesirable effects on the infant

Precautions & Warnings

  • Close observation for patients with severe hepatic, cardiac or renal insufficiency or the elderly
  • Monitoring of renal function, lowest effective dose usage
  • Discontinuation in case of abnormal liver function tests, clinical signs or symptoms consistent with liver disease
  • Precautionary monitoring for patients on long term NSAID treatment

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Store in a dry place
  • Protected from light

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