Diclonac Plus (75 mg+20 mg)/2 ml (IM Injection)

Indications

• Relief of pain and inflammation in various conditions including arthritic conditions, musculoskeletal disorders, trauma-related pain, postoperative pain, renal colic, etc.

Pharmacology

• Potent nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties
• Inhibition of prostaglandin synthesis
• Uricosuric effects
• Action associated with inhibition of cyclooxygenase
• Peak plasma concentration achieved within half an hour following injection
• Lidocaine acts as a local anaesthetic and minimizes pain at the injection site

Dosage & Administration

• Adult dosage: one ampoule once daily by intramuscular injection, and in severe cases, twice daily
• Renal colic: one ampoule once daily intramuscularly, with an option for a second dose after 30 minutes if necessary
• Children dosage: 1-3 mg of Diclofenac Sodium per kg body weight daily in divided doses
• Recommended lowest effective dosage for elderly patients

Interaction

• Potential interactions with Lithium, Digoxin, Anticoagulants, Antidiabetic agents, Cyclosporin, Methotrexate, Quinolone antimicrobials, other NSAIDs and steroids, and diuretics

Contraindications

• Hypersensitivity to Diclofenac and local anaesthetics of the amide type
• Active or suspected peptic ulcer, gastrointestinal bleeding
• Attacks of asthma, urticaria, acute rhinitis precipitated by Aspirin or other NSAIDs
• Adams-Stokes syndrome, severe degrees of heart block, hypersensitivity to excipients used in the formulation

Side Effects

• Mild and transient gastrointestinal discomfort, nausea, diarrhea, and bleeding
• Rare instances of injection site disorder, abscesses, and local necrosis
• Adverse effects due to Lidocaine involving the CNS

Pregnancy & Lactation

• Should not be prescribed during pregnancy unless compelling reasons exist
• Lowest effective dosage should be used, not recommended during the last trimester of pregnancy
• Small quantities may be detected in breast milk with no expected undesirable effects on the infant

Precautions & Warnings

• Close observation for patients with severe hepatic, cardiac, or renal insufficiency, and the elderly
• Monitoring renal function, lowest effective dose usage, and precautionary measures for long-term treatment with NSAIDs

Therapeutic Class

• Drugs for Osteoarthritis
• Drugs used for Rheumatoid Arthritis
• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

• Store at temperature not exceeding 30°C in a dry place, protected from light

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