Diclovir 50 mg (Tablet)

Unit Price: ৳ 0.75 (100's pack: ৳ 75.00)

Medicine Details

Category Details
Generic Diclofenac sodium
Company Virgo pharmaceuticals ltd
Also available as
Diclovir sr 100 mg capsule

Indications

  • Inflammatory and degenerative forms of rheumatism
  • Chronic involutive
  • Polyarthritis
  • Ankylosing spondylarthritis
  • Osteoarthritis
  • Spondylarthroses
  • Acute gout
  • Peri-articular rheumatic disorders
  • Sprain
  • Bruises
  • Dislocations
  • Fractures
  • Soft tissue injuries
  • Surgical interventions
  • Primary dysmenorrhoea
  • Episiotomy
  • Adnexitis
  • Endometritis
  • Parametritis
  • Salpingitis
  • Mastitis
  • Pre-operative medication for the prevention of pain, inflammation, and swelling
  • Post-operative and post-traumatic pain
  • Pain and treatment of inflammation and swelling for patients operated in the urogenital tract, renal and biliary colic

Pharmacology

  • Potent non-steroidal anti-inflammatory drug (NSAID)
  • Anti-rheumatic
  • Analgesic
  • Antipyretic
  • Uricosuric effect
  • Inhibition of prostaglandin biosynthesis
  • Rapid and complete absorption from the gastro-intestinal tract
  • Metabolized in the liver
  • First pass metabolism

Dosage & Administration

  • Adults: 75-150 mg daily in 2 to 3 divided doses
  • Preferably after food
  • Reduction of dose in long term use
  • Diclofenac SR Tablet: 1 tablet daily for adults
  • Children: 1-3 mg of diclofenac/kg body weight daily
  • Elderly patients: Lowest effective dosage is recommended
  • Diclofenac Dispersible Tablet: Recommended daily dosage is 2-3 tablets
  • Maximum daily dose for adults: 150 mg
  • Diclofenac TR Capsule: One capsule daily
  • Diclofenac Suppository: 50 mg suppository 2-3 times daily
  • Maximum daily dose: 150 mg
  • Diclofenac injection: Usual dose is 1 ampoule daily
  • Diclofenac Gel: Applied to the skin 3-4 times daily for external use

Interaction

  • May increase plasma concentrations of lithium and digoxin
  • Isolated reports of an increased risk of hemorrhage with combined use of diclofenac and anticoagulant therapy
  • Can be given together with oral antidiabetic agents without influencing their clinical effect
  • Cases of nephrotoxicity reported in patients receiving cyclosporin and diclofenac concomitantly
  • Serious toxicity reported when methotrexate and NSAIDs are given within 24 hours of each other
  • Convulsions may occur due to an interaction between quinolones and NSAIDs
  • Co-administration of diclofenac with other systemic NSAIDs and steroids may increase unwanted effects
  • Plasma levels of each is lowered with aspirin, although no clinical significance is known

Contraindications

  • Hypersensitivity to any ingredient of the product
  • Peptic ulcer
  • Hypersensitivity to Diclofenac like other non-steroid anti-inflammatory agents
  • Contra-indicated in asthmatic patients in whom attack with asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor
  • Not to be used under occlusive airtight dressings

Side Effects

  • Mild, rare, and transient adverse effects
  • Epigastric pain
  • Eructation
  • Nausea
  • Diarrhea
  • Dizziness
  • Headache
  • Peripheral edema
  • Skin reactions such as rash and eczema
  • Local irritation
  • Reddening of the skin
  • Skin rash

Pregnancy & Lactation

  • Employed only for compelling reasons during pregnancy
  • Lowest effective dose should be used
  • Not recommended during the first trimester of pregnancy
  • Not recommended during pregnancy due to insufficient clinical data
  • Insignificant quantity detected in breast milk with no undesirable effects on the infant

Precautions & Warnings

  • Close observation for peptic ulceration or gastrointestinal bleeding
  • Close observation for patients with advanced age
  • Avoid contact with the eyes or mucus membranes for Diclofenac Gel
  • Hands should be washed properly after application
  • Not to be taken by mouth

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store in a cool and dry place
  • Protected from light
  • Store below 30°C
  • Keep out of the reach of children

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