Difenac 50 mg (Tablet)

Unit Price: ৳ 0.90 (100's pack: ৳ 90.00)

Medicine Details

Category Details
Generic Diclofenac sodium
Company Rephco pharmaceuticals ltd

Indications

  • Rheumatology
  • Inflammatory forms of rheumatism
  • Degenerative forms of rheumatism
  • Chronic involutive
  • Polyarthritis
  • Ankylosing spondylarthritis
  • Osteoarthritis
  • Spondylarthroses
  • Acute gout
  • Peri-articular rheumatic disorders
  • Surgery and Traumatology
  • Sprain
  • Bruises
  • Dislocations
  • Fractures
  • Soft tissue injuries
  • Surgical interventions
  • Obstetrics and Gynecology
  • Primary dysmenorrhoea
  • Episiotomy
  • Adnexitis
  • Endometritis
  • Parametritis
  • Salpingitis
  • Mastitis
  • Otorhinolaryngology
  • Pre-operative medication
  • Dentistry
  • Post-operative pain
  • Post-traumatic pain
  • Inflammation
  • Swelling
  • Other indications
  • Prevention of pain
  • Treatment of inflammation
  • Treatment of swelling
  • Urogenital tract operations
  • Renal colic
  • Biliary colic

Pharmacology

  • Non-steroidal anti-inflammatory drug (NSAID)
  • Anti-rheumatic
  • Anti-inflammatory
  • Analgesic
  • Antipyretic
  • Uricosuric effect
  • Prostaglandin biosynthesis inhibition
  • Rapid and complete absorption
  • Metabolized in the liver
  • First pass metabolism
  • Peak plasma concentrations reached within 2 hours
  • 99.7% bound to plasma proteins

Dosage & Administration

  • Diclofenac FC Tablet for adults: 75-150 mg daily
  • Diclofenac FC Tablet in 2-3 divided doses
  • Reduced dose for long term use
  • Diclofenac SR Tablet for adults: 1 tablet daily
  • Diclofenac SR Tablet for children: 1-3 mg/kg body weight daily
  • Diclofenac SR Tablet for elderly patients: lowest effective dosage recommended
  • Diclofenac Dispersible Tablet for adults: 2-3 tablets daily
  • Maximum daily dose for Diclofenac Dispersible Tablet: 150 mg
  • Diclofenac TR Capsule: One capsule daily
  • Diclofenac Suppository for adults: 50 mg 2-3 times daily
  • Maximum daily dose for Diclofenac Suppository: 150 mg
  • Diclofenac injection: 1 ampoule daily
  • Maximum daily dose for Diclofenac injection: 2 ampoules
  • Diclofenac Gel: 2-4 g applied 3-4 times daily
  • Caution with concomitant therapy

Interaction

  • Increased plasma concentrations of lithium and digoxin
  • Increased risk of hemorrhage with anticoagulant therapy
  • No influence on antidiabetic agents
  • Reported nephrotoxicity with cyclosporin
  • Risk of serious toxicity with methotrexate
  • Potential convulsions with quinolone antimicrobials
  • Increased unwanted effects with other NSAIDs and steroids

Contraindications

  • Hypersensitivity to any ingredient
  • Peptic ulcer
  • Hypersensitivity to Diclofenac
  • Contra-indicated in asthmatic patients
  • Not to be used under occlusive airtight dressings

Side Effects

  • Mild, rare, and transient adverse effects
  • Epigastric pain
  • Eructation
  • Nausea
  • Diarrhea
  • Dizziness
  • Headache
  • Peripheral edema
  • Skin reactions
  • Local irritation
  • Reddening of the skin
  • Skin rash

Pregnancy & Lactation

  • Employed only for compelling reasons during pregnancy
  • Lowest effective dose recommended
  • Not recommended during the first trimester
  • Insignificant quantity in breast milk
  • No undesirable effects on the infant expected

Precautions & Warnings

  • Close observation in instances of peptic ulceration or gastrointestinal bleeding
  • Close observation in elderly patients
  • Avoid contact with eyes or mucous membranes
  • Proper hand washing after application
  • Avoid ingestion

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Cool and dry place
  • Protected from light
  • Store below 30°C
  • Keep out of the reach of children

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