Dix-TR 100 mg (Capsule (Timed Release))

Unit Price: ৳ 2.80 (10 x 10: ৳ 280.00)

Strip Price: ৳ 28.00

Medicine Details

Category	Details
Generic	Diclofenac sodium
Company	Apex pharmaceuticals ltd

Indications

Inflammatory and degenerative forms of rheumatism
Chron ic involutive, polyarthritis, ankylosing spondylarthritis
Osteoarthritis
Sprain
Bruises
Dislocations
Fractures
Soft tissue injuries
Episiotomy
Adnexitis
Endometritis
Parametritis
Salpingitis
Mastitis
Pre-operative medication for the prevention of pain, inflammation, and swelling
Post-operative and post-traumatic pain, inflammation, and swelling
Pain and treatment of inflammation and swelling of patients operated in the urogenital tract, renal and biliary colic

Pharmacology

Potent non-steroidal anti-inflammatory drug (NSAID) with pronounced anti-rheumatic, anti-inflammatory, analgesic, and antipyretic properties. Has uricosuric effect. Inhibits prostaglandin biosynthesis which causes inflammation, pain, and fever. Rapidly and completely absorbed from the gastro-intestinal tract. Metabolized in the liver and undergoes first-pass metabolism.

Dosage & Administration

Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food
1 tablet daily, taken whole with liquid, preferably at meal times
The recommended daily dosage is 2-3 tablets and the maximum daily dose is 150 mg. In milder cases, 2 tablets of Diclofenac DT per day are sufficient
One capsule daily
For adults: 50 mg suppository 2-3 times daily. Maximum daily dose is 150 mg
For external use only. 2-4 g of Diclofenac gel should be applied to the skin 3-4 times daily
Dose should be reduced in long term use
In elderly or debilitated patients, the lowest effective dosage is recommended

Interaction

May increase plasma concentrations of lithium and digoxin
Reports of an increased risk of haemorrhage with the combined use of diclofenac and anticoagulant therapy
Can be given together with oral antidiabetic agents without influencing their clinical effect
Cases of nephrotoxicity reported in patients receiving cyclosporin and diclofenac concomitantly
Caution should be exercised when considering concom itant therapy of NSAID and quinolones
Co-administration with other systemic NSAIDs and steroids may increase the frequency of unwanted effects

Contraindications

Hypersensitive to any ingredient of the product
Peptic ulcer
Hypersensitivity to Diclofenac like other non-steroid anti-inflammatory agents
Contra-indicated in asthmatic patient in whom attack with asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor
Not to be used under occlusive airtight dressings

Side Effects

Adverse effects are mild, rare, and transient
May cause epigastric pain, eructation, nausea, diarrhea, dizziness, headache, peripheral edema, skin rash, and local irritation and reddening of the skin

Pregnancy & Lactation

Should be employed only for compelling reasons during pregnancy. Not recommended during the first trimester of pregnancy or lactation.

Precautions & Warnings

Peptic ulceration or gastrointestinal bleeding may occur in rare instances
Close observation for advanced age patients
Gel should not come in contact with eyes or mucus membranes
Hands should be washed properly after application and not to be taken by mouth

Therapeutic Class

Drugs for Osteoarthritis
Drugs used for Rheumatoid Arthritis
Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children