Edifenac Plus (75 mg+20 mg)/2 ml (IM Injection)

2 ml ampoule: ৳ 15.00 (10's pack: ৳ 150.00)

Medicine Details

Category Details
Generic Diclofenac sodium lidocaine hydrochloride
Company Edruc limited

Indications

  • Relief of all grades of pain and inflammation
  • Arthritic conditions
  • Acute musculoskeletal disorders
  • Pain resulting from trauma
  • Orthopaedic pain
  • Dental pain
  • Postoperative pain
  • Pain of renal colic

Pharmacology

  • Potent nonsteroidal anti-inflammatory drug (NSAID)
  • Marked analgesic and antipyretic properties
  • Uricosuric effects
  • Inhibition of prostaglandin synthesis
  • Rapid peak plasma concentration
  • Local anesthetic effects

Dosage & Administration

  • Adult dosage
  • Renal colic dosage
  • Children dosage
  • Elderly patient dosage

Interaction

  • Increased plasma concentrations of Lithium and Digoxin
  • Risk of haemorrhage with anticoagulant therapy
  • No influence on anticoagulant effect with clinical investigations
  • Can be given together with oral antidiabetic agents
  • Nephrotoxicity with concomitant Cyclosporin
  • Serious toxicity with concomitant Methotrexate and NSAIDs
  • Risk of convulsions with quinolone antimicrobials
  • Increased frequency of unwanted effects with co-administration of other NSAIDs and steroids
  • Inhibition of diuretic activity

Contraindications

  • Hypersensitivity to Diclofenac
  • Active or suspected peptic ulcer or gastrointestinal bleeding
  • Asthma, urticaria, or acute rhinitis precipitated by Aspirin or other NSAIDs
  • Hypersensitivity to local anesthetics of the amide type
  • Adams-Stokes syndrome or severe degrees of heart block
  • Hypersensitivity to excipients used in the formulation

Side Effects

  • Gastrointestinal discomfort
  • Nausea
  • Diarrhea
  • Bleeding
  • Injection site disorder
  • Abscesses
  • Local necrosis
  • CNS-related adverse effects

Pregnancy & Lactation

  • Not recommended during pregnancy
  • Lowest effective dosage should be used
  • Not recommended during the last trimester
  • Very small quantities detected in breast milk

Precautions & Warnings

  • Close observation for patients with severe hepatic, cardiac, or renal insufficiency
  • Deterioration of renal function with NSAID use
  • Monitoring of renal function
  • Discontinuation upon abnormal liver function tests or clinical signs of liver disease
  • Monitoring of patients receiving long term NSAID treatment

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place
  • Protected from light

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