Megafen Plus (75 mg+20 mg)/2 ml (IM Injection)

2 ml ampoule: ৳ 15.05 (2 x 5: ৳ 150.50)

Medicine Details

Category Details
Generic Diclofenac sodium lidocaine hydrochloride
Company Jayson pharmaceuticals ltd

Indications

  • Relieves pain and inflammation in arthritic conditions
  • Manages acute musculoskeletal disorders
  • Treats painful conditions resulting from trauma
  • Serves as local anesthetic for injection site

Pharmacology

  • Potent nonsteroidal antiinflammatory drug
  • Marked analgesic and antipyretic properties
  • Inhibits prostaglandin synthesis
  • Rapid peak plasma concentration

Dosage & Administration

  • Adult dosage: Once daily by intramuscular injection
  • Special dosage for renal colic
  • Children dosage for juvenile chronic arthritis
  • Recommended lowest effective dosage for elderly patients

Interaction

  • May increase plasma concentrations of Lithium and Digoxin
  • Isolated reports of increased risk of hemorrhage with anticoagulants
  • Can be given together with oral antidiabetic agents without influencing their clinical effect
  • Cases of nephrotoxicity reported when given concomitantly with Cyclosporin
  • Serious toxicity reported when given within 24 hours of Methotrexate
  • Caution required when considering concomitant therapy of quinolones and NSAIDs
  • Co-administration with other NSAIDs and steroids may increase unwanted effects
  • Inhibits the activity of diuretics

Contraindications

  • Hypersensitivity to Diclofenac or local anesthetics
  • Active or suspected peptic ulcer or gastrointestinal bleeding
  • Precipitation of asthma, urticaria, or acute rhinitis by Aspirin or other NSAIDs
  • Presence of Adams-Stokes syndrome or severe degrees of heart block
  • Hypersensitivity to any of the excipients used in the formulation

Side Effects

  • Mild and transient side effects
  • Gastrointestinal discomfort, nausea, diarrhea, and occasional bleeding
  • Rare instances of injection site disorder, abscesses, and local necrosis
  • CNS-related adverse effects due to Lidocaine

Pregnancy & Lactation

  • Not recommended during pregnancy unless compelling reasons
  • Lowest effective dosage should be used
  • Not recommended during the last trimester of pregnancy
  • Very small quantities may be detected in breast milk with no expected undesirable effects on the infant

Precautions & Warnings

  • Close observation for patients with severe hepatic, cardiac, or renal insufficiency or the elderly
  • Lowest effective dose should be used for renal insufficiency
  • Monitoring of renal, hepatic function, and blood counts for long-term NSAID treatment

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature not exceeding 30°C in a dry place, protected from light

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