Novarin SR 100 mg (Capsule (Sustained Release))

Unit Price: ৳ 2.50 (100's pack: ৳ 250.00)

Medicine Details

Category	Details
Generic	Diclofenac sodium
Company	Amico laboratories ltd
Also available as	Novarin 1 w gel

Therapeutic Class

Drugs for Osteoarthritis
Drugs used for Rheumatoid Arthritis
Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Indications

Inflammatory and degenerative forms of rheumatism
Chronic involutive polyarthritis
Ankylosing spondylarthritis
Osteoarthritis
Sprain
Bruises
Dislocations
Episiotomy
Adnexitis
Endometritis
Parametritis
Salpingitis
Mastitis
Pre-operative medication for the prevention of pain, inflammation, and swelling
Post-operative and post-traumatic pain, inflammation, and swelling
Prevention of pain and treatment of inflammation and swelling of patients operated in the urogenital tract
Renal and biliary colic

Pharmacology

Potent non-steroidal anti-inflammatory drug (NSAID) with pronounced anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties. Has some uricosuric effect. Inhibits prostaglandin biosynthesis, rapidly and completely absorbed from the gastro-intestinal tract, metabolized in the liver.

Dosage & Administration

Diclofenac FC Tablet: Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food. Dose should be reduced in long term use.
Diclofenac SR Tablet: 1 tablet daily for adults, taken whole with liquid, preferably at meal times. For children: 1-3 mg of diclofenac/kg body wt. daily in divided doses. For elderly patients: lowest effective dosage is recommended.
Diclofenac Dispersible Tablet: Recommended daily dosage is 2-3 tablets for adults, maximum daily dose is 150 mg. For milder cases, 2 tablets of Diclofenac DT per day are sufficient.
Diclofenac TR Capsule: One capsule daily, preferably after mealtimes.
Diclofenac Suppository: For adults: 50 mg suppository 2-3 times daily. Maximum daily dose is 150 mg.
Diclofenac injection: For adults the usual dose is 1 ampoule daily. In serious cases this dose may be increased up to 2 ampoules daily.
Diclofenac Gel: For external use only. 2-4 g of Diclofenac gel should be applied to the skin 3-4 times daily.

Interaction

Lithium and digoxin: May increase plasma concentrations
Anticoagulants: Isolated reports of an increased risk of haemorrhage
Antidiabetic agents: Clinical studies have shown that diclofenac can be given together with oral antidiabetic agents without influencing their clinical effect
Cyclosporin: Cases of nephrotoxicity have been reported
Methotrexate: Cases of serious toxicity have been reported when methotrexate and NSAIDs are given within 24 hours of each other
Quinolone antimicrobials: Convulsions may occur due to an interaction between quinolones and NSAIDs
Other NSAIDs and steroids: Co-administration of diclofenac with other systemic NSAIDs and steroids may increase the frequency of unwanted effects

Contraindications

Patients hypersensitive to any ingredient of the products
Peptic ulcer
Hypersensitivity to Diclofenac like other non-steroid anti-inflammatory agents
Asthmatic patients in whom attack with asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor
Not to be used under occlusive airtight dressings

Side Effects

Epigastric pain
Eructation
Nausea
Diarrhea
Dizziness
Headache
Peripheral edema
Skin reactions such as rash and eczema
Local irritation and reddening of the skin
Skin rash

Pregnancy & Lactation

Employed only for compelling reasons during pregnancy
Lowest effective dose should be used
Not recommended during the first trimester of pregnancy
Not recommended during lactation

Precautions & Warnings

Rare instances of peptic ulceration or gastrointestinal bleeding
Close observation for patients with advanced age
Avoid contact with eyes or mucus membranes
Not to be taken by mouth

Storage Conditions

Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children.