Orafen SR 100 mg (Tablet (Sustained Release))
Medicine Details
| Category | Details |
|---|---|
| Generic | Diclofenac sodium |
| Company | Rangs pharmaceuticals ltd |
Indications
- Inflammatory and degenerative forms of rheumatism
- Chronic involutive polyarthritis
- Ankylosing spondylarthritis
- Osteoarthritis
- Spondylarthroses
- Acute gout
- Peri-articular rheumatic disorders
- Sprain
- Bruises
- Dislocations
- Fractures
- Soft tissue injuries
- Surgical interventions
- Primary dysmenorrhoea
- Episiotomy
- Adnexitis
- Endometritis
- Parametritis
- Salpingitis
- Mastitis
- Pre-operative medication for the prevention of pain
- Inflammation
- Swelling
- Post-operative pain
- Post-traumatic pain
- Pain and treatment of inflammation and swelling of patients operated in the urogenital tract
- Renal and biliary colic
Pharmacology
Potent non-steroidal anti-inflammatory drug (NSAID) with pronounced anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties
Dosage & Administration
- Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food
- Children: 1-3 mg of diclofenac/kg body wt. daily in divided doses
- Elderly patients: Lowest effective dosage is recommended
- Recommended daily dosage is 2-3 tablets for adults
- Maximum daily dose is 150 mg
- One capsule daily
- For adults: 50 mg suppository 2-3 times daily
- External use: 2-4 g of Diclofenac gel should be applied to the skin 3-4 times daily
Interaction
- Increased plasma concentrations of lithium and digoxin
- Increased risk of haemorrhage with the combined use of diclofenac and anticoagulant therapy
- Can be given together with oral antidiabetic agents without influencing their clinical effect
- Cases of nephrotoxicity reported in patients receiving cyclosporin and diclofenac concomitantly
- Serious toxicity reported when methotrexate and NSAIDs are given within 24 hours of each other
- Convulsions may occur due to interaction between quinolones and NSAIDs
- Co-administration of diclofenac with other systemic NSAIDs and steroids may increase the frequency of unwanted effects
Contraindications
Hypersensitive to any ingredient of the products, peptic ulcer, hypersensitivity to Diclofenac like other non-steroid anti-inflammatory agents, not recommended under occlusive airtight dressings
Side Effects
- Epigastric pain
- Eructation
- Nausea
- Diarrhea
- Dizziness
- Headache
- Peripheral edema
- Rash
- Eczema
- Local irritation
- Reddening of the skin
- Skin rash
Pregnancy & Lactation
Diclofenac should be employed only for compelling reasons during pregnancy. Not recommended during the first trimester of pregnancy. Insignificant quantity may be detected in breast milk but no undesirable effects on the infant expected
Precautions & Warnings
- Close observation in rare instances of peptic ulceration or gastrointestinal bleeding
- Close observation in patients with advanced age
- Gel should not be allowed to come in contact with the eyes or mucus membranes
- Hands should be washed properly after application
- Not to be taken by mouth
Therapeutic Class
Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
Cool and dry place, protected from light, store below 30°C, keep out of the reach of children