Orfenac-TR 100 mg (Capsule (Timed Release))

Unit Price: ৳ 3.01 (5 x 10: ৳ 150.50)

Strip Price: ৳ 30.10

Medicine Details

Category	Details
Generic	Diclofenac sodium
Company	Orion pharma ltd

Indications

Inflammatory and degenerative forms of rheumatism
Chronic involutive
Polyarthritis
Ankylosing spondylarthritis
Osteoarthritis
Spondylarthroses
Acute gout
Sprain
Bruises
Dislocations
Fractures
Soft tissue injuries
Surgical interventions
Primary dysmenorrhoea
Episiotomy
Adnexitis
Endometritis
Parametritis
Salpingitis
Mastitis
Pre-operative medication for the prevention of pain, inflammation, and swelling
Post-operative and post-traumatic pain, inflammation, and swelling
Prevention of pain and treatment of inflammation and swelling of patients operated in the urogenital tract
Renal and biliary colic

Pharmacology

Potent non-steroidal anti-inflammatory drug (NSAID)
Anti-rheumatic
Analgesic
Antipyretic
Uricosuric effect
Inhibition of prostaglandin biosynthesis
Rapid and complete absorption from the gastro-intestinal tract
Peak plasma concentrations reached within an average of 2 hours after ingestion
99.7% bound to plasma proteins
Metabolized in the liver

Dosage & Administration

Adult dosage: 75-150 mg daily in 2 to 3 divided doses
Dose reduction in long term use
Children dosage: 1-3 mg of diclofenac/kg body weight daily in divided doses
Elderly patients: Lowest effective dosage recommended
Maximum daily dosage: 150 mg
Diclofenac gel application: 2-4 g to the skin 3-4 times daily

Interaction

Increased plasma concentrations of lithium and digoxin
Risk of haemorrhage with anticoagulant therapy
No influence on antidiabetic agents' clinical effect
Cases of nephrotoxicity with concomitant use of cyclosporin
Serious toxicity when used with methotrexate
Potential convulsions due to an interaction with quinolone antimicrobials
Increased frequency of unwanted effects when co-administered with other NSAIDs and steroids

Contraindications

Hypersensitivity to any ingredient of the product
Peptic ulcer
Hypersensitivity to Diclofenac or other non-steroid anti-inflammatory agents
Contra-indicated in asthmatic patients

Side Effects

Mild, rare, and transient adverse effects
Epigastric pain
Eructation
Nausea
Diarrhea
Dizziness
Headache
Peripheral edema
Skin reactions such as rash and eczema
Local irritation and reddening of the skin
Skin rash

Pregnancy & Lactation

Use during pregnancy only for compelling reasons
Lowest effective dose should be used
Not recommended during the first trimester of pregnancy
Not recommended during lactation

Precautions & Warnings

Close observation for peptic ulceration or gastrointestinal bleeding
Keep out of contact with eyes or mucus membranes
Proper hand hygiene after application
Not to be taken by mouth

Therapeutic Class

Drugs for Osteoarthritis
Drugs used for Rheumatoid Arthritis
Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Cool and dry place
Protected from light
Store below 30°C
Keep out of the reach of children

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