Orfenac Plus (75 mg+20 mg)/2 ml (IM Injection)

2 ml ampoule: ৳ 9.06 (2 x 5: ৳ 90.60)

Medicine Details

Category Details
Generic Diclofenac sodium lidocaine hydrochloride
Company Orion pharma ltd

Indications

  • Relieves pain and inflammation
  • Treatment for arthritic conditions
  • Treatment for musculoskeletal disorders
  • Pain relief for traumatic conditions
  • Acts as a local anaesthetic

Pharmacology

  • Potent nonsteroidal antiinflammatory drug (NSAID)
  • Marked analgesic and antipyretic properties
  • Inhibits prostaglandin synthesis
  • Rapid onset and stable local anaesthetic

Dosage & Administration

  • Adult dosage instructions
  • Renal colic treatment dosage
  • Children's dosage for juvenile chronic arthritis
  • Recommended dosage for elderly patients

Interaction

  • Potential interactions with lithium and digoxin
  • Possible risk of haemorrhage with anticoagulants
  • Clinical studies on interaction with antidiabetic agents
  • Reported cases of nephrotoxicity with cyclosporin
  • Serious toxicity when combined with methotrexate
  • Caution required when used with quinolone antimicrobials
  • Potential increase in unwanted effects with other NSAIDs and steroids
  • Risk of inhibiting the activity of diuretics

Contraindications

  • Hypersensitivity to Diclofenac or local anaesthetics
  • Active or suspected peptic ulcer or gastrointestinal bleeding
  • Contradicted in patients with asthma, urticaria, or acute rhinitis triggered by NSAIDs
  • Presence of excipients used in the formulation

Side Effects

  • Mild and transient side effects
  • Gastrointestinal discomfort, nausea, and diarrhea
  • Bleeding and injection site disorders
  • Rare instances of abscesses and local necrosis
  • Adverse effects such as drowsiness, dizziness, and confusion

Pregnancy & Lactation

  • Not recommended during pregnancy without compelling reasons
  • Lowest effective dosage should be used
  • Not recommended during the last trimester of pregnancy
  • Small quantities may be detected in breast milk

Precautions & Warnings

  • Close observation for patients with severe hepatic, cardiac, or renal insufficiency
  • Monitoring of renal function for patients on NSAIDs
  • Discontinuation if abnormal liver function tests persist or worsen
  • Monitoring of long-term NSAID treatment patients

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place
  • Protected from light

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