Orgafen TR 100 mg (Capsule (Timed Release))

Unit Price: ৳ 3.01 (10 x 10: ৳ 301.00)

Strip Price: ৳ 30.10

Medicine Details

Category	Details
Generic	Diclofenac sodium
Company	Novatek pharmaceuticals ltd

Indications

Rheumatology
Inflammatory and degenerative forms of rheumatism
Chronic involutive
Polyarthritis
Ankylosing spondylarthritis
Osteoarthritis
Sprain
Bruises
Dislocations
Fractures
Soft tissue injuries
Surgical interventions
Obstetrics and Gynecology
Episiotomy
Adnexitis
Endometritis
Parametritis
Salpingitis
Mastitis
Otorhinolaryngology
Dentistry
Urogenital tract
Renal and biliary colic

Pharmacology

Potent non-steroidal anti-inflammatory drug (NSAID) with pronounced anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties. Also has some uricosuric effect. Inhibits prostaglandin biosynthesis which plays a major role in causing inflammation, pain and fever.

Dosage & Administration

Diclofenac FC Tablet: 75-150 mg daily in 2 to 3 divided doses, preferably after food. Dose should be reduced in long term use.
Diclofenac SR Tablet: 1 tablet daily for adults, 1-3 mg of diclofenac/kg body wt. daily in divided doses for children. Lowest effective dosage for elderly patients.
Diclofenac Dispersible Tablet: 2-3 tablets daily for adults, 1-3 mg/kg body weight for children.
Diclofenac TR Capsule: One capsule daily, preferably after mealtimes.
Diclofenac Suppository: 50 mg suppository 2-3 times daily for adults, maximum daily dose is 150 mg.
Diclofenac injection: 1 ampoule daily for adults, up to 2 ampoules daily in serious cases.
Diclofenac Gel: 2-4 g applied to the skin 3-4 times daily for external use.

Interaction

Lithium and digoxin: May increase plasma concentrations of lithium and digoxin.
Anticoagulants: Isolated reports of increased risk of hemorrhage.
Antidiabetic agents: Can be given together with oral antidiabetic agents without influencing their clinical effect.
Cyclosporin: Cases of nephrotoxicity reported in patients receiving cyclosporin and diclofenac concomitantly.
Methotrexate: Serious toxicity reported when methotrexate and NSAIDs are given within 24 hours of each other.
Quinolone antimicrobials: Caution should be exercised when considering concomitant therapy of NSAID and quinolones.
Other NSAIDs and steroids: Co-administration may increase the frequency of unwanted effects.

Contraindications

Hypersensitivity to any ingredient of the products
Peptic ulcer
Hypersensitivity to Diclofenac like other non-steroid anti-inflammatory agents
Not to be used under occlusive airtight dressings

Side Effects

Mild, rare and transient
Epigastric pain
Eructation
Nausea
Diarrhea
Dizziness
Peripheral edema
Skin reactions
Rash
Eczema
Local irritation and reddening of the skin
Skin rash

Pregnancy & Lactation

Should be employed only for compelling reasons during pregnancy. Lowest effective dose should be used. Not recommended during the first trimester of pregnancy. Not recommended during breastfeeding.

Precautions & Warnings

Keep patients under close observation if peptic ulceration or gastrointestinal bleeding occurs
Should not come in contact with the eyes or mucus membranes
Hands should be washed properly after application
Not to be taken by mouth

Therapeutic Class

Drugs for Osteoarthritis
Drugs used for Rheumatoid Arthritis
Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children.