Penac TR 100 mg (Capsule (Timed Release))

Unit Price: ৳ 3.00 (50's pack: ৳ 150.00)

Medicine Details

Category Details
Generic Diclofenac sodium
Company Apc pharma ltd
Also available as
Penac 50 mg tablet

Indications

  • Rheumatology
  • Inflammatory forms of rheumatism
  • Degenerative forms of rheumatism
  • Chronic involutive
  • Polyarthritis
  • Ankylosing spondylarthritis
  • Osteoarthritis
  • Spondylarthroses
  • Acute gout
  • Peri-articular rheumatic disorders
  • Sprain
  • Bruises
  • Dislocations
  • Fractures
  • Soft tissue injuries
  • Surgical interventions
  • Primary dysmenorrhoea
  • Episiotomy
  • Adnexitis
  • Endometritis
  • Parametritis
  • Salpingitis
  • Mastitis
  • Pre-operative medication for pain prevention
  • Pre-operative medication for inflammation prevention
  • Pre-operative medication for swelling prevention
  • Post-operative pain treatment
  • Post-operative inflammation treatment
  • Post-operative swelling treatment
  • Urogenital tract pain prevention
  • Renal colic pain prevention
  • Biliary colic pain prevention

Pharmacology

  • Potent non-steroidal anti-inflammatory drug (NSAID)
  • Anti-rheumatic
  • Anti-inflammatory
  • Analgesic
  • Antipyretic
  • Uricosuric effect
  • Inhibition of prostaglandin biosynthesis
  • Rapid and complete absorption from the gastro-intestinal tract
  • Peak plasma concentrations reached within 2 hours
  • 99.7% bound to plasma proteins
  • Metabolized in the liver
  • Undergoes first pass metabolism

Dosage & Administration

  • Dose for adults: 75-150 mg daily
  • Dose to be divided in 2 to 3 doses
  • Preferred to be taken after food
  • Dosage reduction for long term use
  • Dosage for children: 1-3 mg/kg body weight daily in divided doses
  • Recommended daily dosage for Diclofenac Dispersible Tablet: 2-3 tablets
  • Maximum daily dose for Diclofenac Dispersible Tablet: 150 mg
  • Recommended to be taken before meals
  • Dosage of Diclofenac TR Capsule: One capsule daily
  • Preferred to be taken after meals

Interaction

  • Potential drug interactions with Lithium and digoxin
  • Potential increased risk of haemorrhage with anticoagulants
  • Clinically insignificant influence on antidiabetic agents
  • Potential nephrotoxicity with cyclosporin
  • Potential serious toxicity with methotrexate
  • Potential convulsions with quinolone antimicrobials
  • Increased frequency of unwanted effects with co-administration of other NSAIDs and steroids

Contraindications

  • Contraindicated in patients hypersensitive to any ingredient
  • Contraindicated in patients with peptic ulcer
  • Contraindicated in patients with hypersensitivity to Diclofenac or other non-steroid anti-inflammatory agents
  • Contraindicated in asthmatic patients with precipitated attacks

Side Effects

  • Mild, rare and transient adverse effects
  • Possible complaints of epigastric pain, eructation, nausea, diarrhea, dizziness, and headache
  • Possible peripheral edema and skin reactions such as rash and eczema
  • Potential local irritation and reddening of the skin with Gel application

Pregnancy & Lactation

  • Use during pregnancy only for compelling reasons
  • Lowest effective dose recommended during pregnancy
  • Not recommended during the first trimester of pregnancy
  • Not recommended during breastfeeding
  • Insignificant quantity may be detected in breast milk with no expected undesirable effects on the infant

Precautions & Warnings

  • Close observation in instances of peptic ulceration or gastrointestinal bleeding
  • Close observation in advanced age patients
  • Avoid contact with eyes or mucus membranes with Gel application
  • Proper hand washing after application

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store in a cool and dry place
  • Protect from light
  • Store below 30°C
  • Keep out of the reach of children

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