Proflam 50 mg (Tablet)

Unit Price: ৳ 0.51 (100's pack: ৳ 50.69)

Medicine Details

Category	Details
Generic	Diclofenac sodium
Company	Novo healthcare and pharma ltd
Also available as	Proflam sr 100 mg tablet

Indications

Rheumatology
Inflammatory disorders
Degenerative rheumatism
Polyarthritis
Ankylosing spondylarthritis
Osteoarthritis
Sprain relief
Bruise relief
Dislocation relief
Fracture relief
Soft tissue injury relief
Pain relief after surgical interventions
Primary dysmenorrhoea relief
Episiotomy recovery
Adnexitis relief
Endometritis relief
Parametritis relief
Salpingitis relief
Mastitis relief
Pre-operative medication for pain prevention
Pre-operative medication for inflammation prevention
Pre-operative medication for swelling prevention
Post-operative pain relief
Post-traumatic pain relief
Inflammation treatment
Swelling treatment
Urogenital tract pain prevention
Urogenital tract inflammation treatment
Renal colic pain prevention
Renal colic inflammation treatment
Biliary colic pain prevention
Biliary colic inflammation treatment

Pharmacology

Potent non-steroidal anti-inflammatory drug (NSAID)
Pronounced anti-rheumatic properties
Anti-inflammatory properties
Analgesic properties
Antipyretic properties
Uricosuric effect
Inhibits prostaglandin biosynthesis
Rapid and complete absorption from the gastrointestinal tract
Peak plasma concentrations reached within 2 hours
High plasma protein binding (99.7%)
Metabolized in the liver
Undergoes first pass metabolism

Dosage & Administration

Adult dosage range: 75-150 mg daily
Divided doses
Administered preferably after food
Dose reduction for long term use
Children dosage range: 1-3 mg of diclofenac/kg body weight daily
Elderly patients dosage considerations
Maximum daily dosage: 150 mg
For diclofenac gel: 2-4 g application 3-4 times daily
External use only
Diclofenac suppository adult dosage: 50 mg 2-3 times daily
Maximum suppository daily dose: 150 mg
Diclofenac injection usual adult dose: 1 ampoule daily
Maximum injection daily dose: 2 ampoules

Interaction

Potential drug interactions with lithium and digoxin
Increased risk of haemorrhage with anticoagulants
Can be given with oral antidiabetic agents
Risk of nephrotoxicity with cyclosporin
Potential serious toxicity when combined with methotrexate
Caution required when used concomitantly with quinolone antimicrobials
Increased risk of unwanted effects with other NSAIDs and steroids
Lowered plasma levels when used with aspirin

Contraindications

Hypersensitivity to any ingredient
Peptic ulcer
Hypersensitivity to Diclofenac
Contraindicated in asthmatic patients with specific trigger conditions
Not to be used under occlusive airtight dressings

Side Effects

Mild, rare, and transient adverse effects
Possible initial complaints of epigastric pain, eructation, nausea, diarrhea, dizziness, headache
Encountered peripheral edema, rash, eczema
Local irritation and reddening of the skin from gel application

Pregnancy & Lactation

Use during pregnancy only for compelling reasons
Lowest effective dose to be used during pregnancy
Not recommended during the first trimester of pregnancy
Insignificant quantity detected in breast milk

Precautions & Warnings

Close observation for peptic ulceration or gastrointestinal bleeding
Cautions for patients of advanced age
Avoid contact with eyes or mucus membranes
Avoid ingestion

Therapeutic Class

Drugs for Osteoarthritis
Drugs for Rheumatoid Arthritis
Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store in a cool and dry place
Protected from light
Store below 30°C
Keep out of the reach of children

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