Refain 75 mg/3 ml (IM Injection)
3 ml ampoule: ৳ 9.50 (10's pack: ৳ 95.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diclofenac sodium |
| Company | Monicopharma ltd |
| Also available as |
Indications
- Inflammatory rheumatism
- Degenerative rheumatism
- Polyarthritis
- Ankylosing spondylarthritis
- Osteoarthritis
- Spondylarthroses
- Acute gout
- Peri-articular rheumatic disorders
- Sprain
- Bruises
- Dislocations
- Fractures
- Soft tissue injuries
- Surgical interventions
- Primary dysmenorrhoea
- Episiotomy
- Adnexitis
- Endometritis
- Parametritis
- Salpingitis
- Mastitis
- Pre-operative medication
- Post-operative pain relief
- Post-traumatic pain relief
- Renal and biliary colic prevention
- Urogenital tract pain prevention
- Inflammation treatment
- Swelling treatment
Pharmacology
- Non-steroidal anti-inflammatory drug (NSAID)
- Anti-rheumatic
- Analgesic
- Antipyretic
- Uricosuric effect
- Inhibition of prostaglandin biosynthesis
- Rapid and complete absorption
- High plasma protein binding
- Liver metabolism
- First pass metabolism
Dosage & Administration
- Adult dosage 75-150mg daily
- Divided doses
- Preferably after food
- Reduced dosage for long term use
- Children dosage based on body weight
- Elderly patients dosage reduction
- Maximum daily dose 150mg
- Surface area dependent external gel application
- Suppository dosage
- Maximum of 2 ampoules of injection daily
Interaction
- Increased plasma concentration of lithium and digoxin
- Risk of hemorrhage with anticoagulants
- No influence on antidiabetic agents
- Nephrotoxicity with cyclosporine
- Toxicity with methotrexate
- Increased risk of convulsions with quinolones
- Increased unwanted effects with other NSAIDs and steroids
Contraindications
- Hypersensitivity to any ingredient
- Peptic ulcer
- Hypersensitivity to Diclofenac or other NSAIDs
- Asthmatic patients with specific reactions to acetylsalicylic acid or prostaglandin synthetase inhibitors
- Avoid use under occlusive dressings
Side Effects
- Mild, rare and transient adverse effects
- Epigastric pain
- Eructation
- Nausea
- Diarrhea
- Dizziness
- Headache
- Peripheral edema
- Skin reactions
- Local skin irritation and reddening
Pregnancy & Lactation
- Use only for compelling reasons during pregnancy
- Lowest effective dose during pregnancy
- Not recommended in first trimester of pregnancy
- Not recommended during lactation due to minimal transfer to breast milk
Precautions & Warnings
- Close observation for peptic ulceration or gastrointestinal bleeding
- Monitoring in advanced age patients
- Avoid contact with eyes or mucus membranes
- Avoid oral ingestion
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Cool and dry storage
- Protected from light
- Below 30°C
- Keep out of reach of children
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