ATV 10 mg (Tablet)

Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Delta pharma ltd
Also available as
Atv 20 mg tablet Atv 40 mg tablet

Title

Atorvastatin Calcium Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

Atorvastatin is indicated as an adjunct to diet to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels in various diseases such as familial hypercholesterolaemia, mixed dyslipidemia, hypertriglyceridemia, dysbetalipoproteinaemia, and coronary artery disease.

Dosage and administration

  • Adults: Usually 10 mg once daily; maximum 80 mg once daily
  • Children (10-18 years): Initially 10 mg once daily, increased if necessary to max. 20 mg once daily

Interaction

  • Coadministration of cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals may increase myopathy risk
  • Antacid and colestipol may affect plasma concentrations of atorvastatin
  • Digoxin levels may increase when coadministered with atorvastatin
  • Atorvastatin may affect oral contraceptive AUC values, should be considered when selecting an oral contraceptive

Contraindications

  • Hypersensitivity to any component of this medication
  • Active liver disease or unexplained persistent elevations of serum transaminases
  • History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side effects

  • Constipation
  • Flatulence
  • Dyspepsia
  • Abdominal pain
  • Infection
  • Headache
  • Back pain
  • Rash
  • Asthenia
  • Arthralgia
  • Myalgia

Pregnancy and lactation

  • Pregnancy: Atorvastatin is contraindicated during pregnancy due to potential congenital anomalies and toxicity to reproduction
  • Lactation: Not known whether atorvastatin or its metabolites are excreted in human milk; contraindicated during breastfeeding

Precautions and warnings

  • Liver function tests should be performed before the initiation of treatment and periodically thereafter
  • ATV should be used with caution in patients who consume substantial quantities of alcohol or have a history of liver disease

Mode of action

Selective inhibitor of HMG-CoA reductase, lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and increases the number of hepatic LDL receptors

Indications

  • Reduction of total cholesterol and LDL cholesterol in patients with familial hypercholesterolaemia
  • Treatment of patients with dysbetalipoproteinaemia and hypertriglyceridemia
  • Reduction of cardiac ischaemic events in patients with asymptomatic or mild to moderate symptomatic coronary artery disease

Storage conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Pharmacology

  • Absorption: Rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours
  • Distribution: Mean volume of distribution is approximately 381 liters; 98% bound to plasma proteins
  • Metabolism: Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products. Atorvastatin metabolism by cytochrome P450 3A4
  • Excretion: Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism

Use in special populations

  • Geriatric: Plasma concentrations are higher in healthy elderly subjects compared to young adults
  • Pediatric: Pharmacokinetic data in the pediatric population are not available
  • Gender: No clinically significant difference in LDL-C reduction between men and women
  • Renal insufficiency: No influence on the plasma concentrations or LDL-C reduction of ATV
  • Hepatic insufficiency: In patients with chronic alcoholic liver disease, plasma concentrations of ATV are markedly increased

Overdose effects

Specific treatment is not available for atorvastatin overdose; patient should be treated symptomatically and supportive measures instituted

Drug classes

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Compound summary

  • Molecular formula: C33H35FN2O5
  • Chemical structure: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg

Common questions

  • What is ATV 10 mg Tablet?
  • How should I take ATV 10 mg Tablet?
  • What are the uses of ATV 10 mg Tablet?
  • What are the Side Effects of ATV 10 mg Tablet?
  • What are the instructions for storage and disposal ATV 10 mg Tablet?
  • Is ATV 10 mg Tablet used for lowering cholesterol?
  • Will taking ATV 10 mg Tablet increase my risk of diabetes?
  • For how long do I need to take ATV 10 mg Tablet? Is it safe for long-term use?
  • Does ATV 10 mg Tablet cause weight loss?
  • Can I stop taking ATV 10 mg Tablet?
  • Does ATV 10 mg Tablet cause memory loss?
  • Does ATV 10 mg Tablet make you tired?
  • Can ATV 10 mg Tablet be prescribed to children?
  • Is ATV 10 mg Tablet a blood thinner?
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