Tolfenac Plus (75 mg+20 mg)/2 ml (IM Injection)

2 ml ampoule: ৳ 12.00 (10's pack: ৳ 120.00)

Medicine Details

Category Details
Generic Diclofenac sodium lidocaine hydrochloride
Company Globex pharmaceuticals ltd

Indications

  • Relief of all grades of pain and inflammation
  • Arthritic conditions
  • Musculoskeletal disorders
  • Pain resulting from trauma
  • Postoperative pain
  • Renal colic

Pharmacology

  • Potent nonsteroidal antiinflammatory drug (NSAID)
  • Marked analgesic and antipyretic properties
  • Inhibition of prostaglandin synthesis
  • Rapid action of Lidocaine as local anaesthetic
  • Impairment of nerve impulse conduction by Lidocaine

Dosage & Administration

  • Adult dosage
  • Renal colic dosage
  • Children dosage for Juvenile chronic arthritis
  • Dosage for elderly patients

Interaction

  • Increased plasma concentrations of Lithium and Digoxin with Diclofenac
  • Possible risk of haemorrhage with Diclofenac and anticoagulant therapy
  • Ability to be given together with oral antidiabetic agents without influencing their clinical effect
  • Reported cases of nephrotoxicity with Cyclosporin and Diclofenac concomitantly
  • Reported cases of serious toxicity with Methotrexate and NSAIDs given within 24 hours of each other
  • Possible convulsions due to interaction between quinolones and NSAIDs
  • Increased frequency of unwanted effects with co-administration of Diclofenac with other systemic NSAIDs and steroids
  • Possible inhibition of diuretic activity by various NSAIDs

Contraindications

  • Hypersensitivity to Diclofenac
  • Active or suspected peptic ulcer or gastrointestinal bleeding
  • Attacks of asthma, urticaria or acute rhinitis precipitated by Aspirin or other NSAIDs
  • Hypersensitivity to local anaesthetics of the amide type
  • Adams-Stokes syndrome or severe degrees of heart block
  • Hypersensitivity to any of the excipients used in the formulation

Side Effects

  • Mild and transient side effects
  • Gastrointestinal discomfort
  • Nausea
  • Diarrhea
  • Bleeding
  • Injection site disorder
  • Abscesses and local necrosis in rare instances
  • CNS reactions including drowsiness, dizziness, and confusion

Pregnancy & Lactation

  • Not recommended during pregnancy unless compelling reasons exist
  • Use lowest effective dosage during pregnancy
  • Not recommended during the last trimester of pregnancy
  • Small quantities may be detected in breast milk with no expected undesirable effects on the infant

Precautions & Warnings

  • Close observation of patients with severe hepatic, cardiac or renal insufficiency or the elderly
  • Use of lowest effective dose and monitoring of renal function in such patients
  • Discontinuation of Diclofenac if abnormal liver function tests or other manifestations occur
  • Monitoring of long term NSAID treatments for renal, hepatic function, and blood counts

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Store in a dry place
  • Protected from light

Related Brands