Intafenac K 50 mg (Tablet)

Indications

• Short-term treatment for post-traumatic pain
• Management of post-operative pain and inflammation
• Treatment of painful and/or inflammatory conditions in gynaecology
• Relief from migraine attacks
• Management of painful syndromes of the vertebral column
• Use in non-articular rheumatism
• Adjuvant therapy in painful inflammatory infections of the ear, nose, or throat

Pharmacology

• Inhibition of cyclooxygenase (COX-1 and COX-2)
• Potent inhibitor of prostaglandin synthesis
• Sensitizes afferent nerves and potentiate the action of bradykinin
• Mediator of inflammation

Dosage & Administration

• Initial loading dose of 50 mg for adults
• 25-50 mg to be taken every eight hours if necessary for adults
• Initial loading dose of 50 mg for migraine, then further 25-50 mg after 2 hours if necessary
• Maximum daily dose of 150 mg for migraine
• Upto 75 mg daily in divided doses for children over 14 years of age

Interaction

• Potential drug interactions with Lithium and Digoxin
• Increased risk of hemorrhage with anticoagulant therapy
• Reports of nephrotoxicity with concomitant use of Cyclosporin
• Potential for serious toxicity when used with Methotrexate within 24 hours
• Inhibition of diuretic activity when used with diuretics
• Increased frequency of unwanted effects when co-administered with other NSAIDs and steroids

Contraindications

• Contraindicated in patients with known hypersensitivity to Diclofenac
• Not to be given to patients who have experienced asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
• Contraindicated for perioperative pain in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

• Mild and transient side-effects
• Occasional: epigastric pain, nausea, vomiting, diarrhea
• Rare: gastrointestinal bleeding, peptic ulcer, bloody diarrhea

Pregnancy & Lactation

• Not prescribed during pregnancy unless compelling reasons
• Lowest effective dosage should be used during pregnancy
• Not recommended during the last trimester of pregnancy
• Small quantities may be detected in breast milk

Therapeutic Class

• Drugs for Osteoarthritis
• Drugs used for Rheumatoid Arthritis
• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

• Keep below 30°C temperature
• Away from light and moisture
• Keep out of the reach of children

Related Brands

• A-Fenac K 50 mg (Tablet) - acme-laboratories-ltd