Cox-E 60 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Etoricoxib |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Relief of Osteoarthritis
- Relief of Rheumatoid arthritis
- Relief of Ankylosing spondylitis
- Relief of acute gouty arthritis pain and signs of inflammation
- Treatment of moderate pain associated with dental surgery
Pharmacology
- Potent, orally active COX-2 specific inhibitor
- Inhibition of COX-2 decreases pain, inflammation, and fever symptoms
- Decreased potential for gastrointestinal toxicity and effects on platelet aggregation
- Dose-dependent inhibition of COX-2 without inhibition of COX-1
Dosage & Administration
- Recommended dose for Osteoarthritis: 30 mg once daily, increased to 60 mg if needed
- Recommended dose for Rheumatoid arthritis: 90 mg once daily
- Recommended dose for Ankylosing spondylitis: 90 mg once daily
- Recommended dose for acute gouty arthritis: 120 mg once daily for 8 days
- Recommended dose for postoperative dental surgery pain: 90 mg once daily for a maximum of 3 days
Interaction
- Increased prothrombin time with oral anticoagulants
- Potential reduction of diuretics and antihypertensive drugs effects with NSAIDs
- Concomitant use with low-dose acetylsalicylic acid for cardiovascular prophylaxis
- Potential increase in nephrotoxic effects with ciclosporin or tacrolimus coadministration
- Decreased lithium renal excretion leading to increased plasma levels
Contraindications
- Hypersensitivity to active substance or excipients
- Active peptic ulceration or gastrointestinal bleeding
- History of bronchospasm, acute rhinitis, nasal polyps, or allergic-type reactions to NSAIDs including COX-2 inhibitors
- Pregnancy and lactation
- Severe hepatic dysfunction
- Estimated renal creatinine clearance <30 ml/min
- Inflammatory bowel disease
- Congestive heart failure
- Uncontrolled hypertension
- Established ischaemic heart disease, peripheral arterial disease, or cerebrovascular disease
Side Effects
- Palpitation
- Fatigue
- Influenza-like symptoms
- Ecchymosis
- Dry mouth
- Taste disturbance
- Atrial fibrillation
- Transient ischaemic attack
- Chest pain
- Flushing
- Cough
- Dyspnoea
- Epistaxis
- Anxiety
- Impaired mental acuity
- Paraesthesia
- Electrolyte disturbance
- Myalgia
- Arthralgia
- Confusion
- Hallucinations
Pregnancy & Lactation
- Not recommended for women attempting to conceive
- Lactating women should not breastfeed while using the product
Precautions & Warnings
- Caution in patients at risk of gastrointestinal complications with NSAIDs
- Careful consideration for patients with significant risk factors for cardiovascular events
- Monitoring of renal function in patients at risk
- Caution in patients with cardiac failure, left ventricular dysfunction, or hypertension
- Monitoring of liver function and discontinuation if hepatic insufficiency occurs
- Discontinuation at the first sign of hypersensitivity
- Potential masking of fever and inflammation symptoms
- Caution when co-administering with warfarin or other oral anticoagulants
Overdose Effects
- Single doses up to 500 mg did not result in significant toxicity
- Usual supportive measures in case of overdose
Therapeutic Class
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Store below 30°C
- Protect from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula : C18H15ClN2O2S
Common Questions about Cox-E 60 mg Tablet
- Selective COX-2 inhibitor
- Indicated for Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis
- Duration of effect: 20-24 hours
- Onset of action: Within 1-2 hours, faster on empty stomach
- Not recommended for pregnant and breastfeeding women
- No habit-forming tendencies
- Unsafe to consume with alcohol
- Affects alertness, patient should avoid driving
- Caution in patients with kidney and liver disease
- Regular blood pressure monitoring advised