Cox-E 90 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Indications

  • Symptomatic relief of Osteoarthritis (OA)
  • Symptomatic relief of Rheumatoid arthritis (RA)
  • Symptomatic relief of Ankylosing spondylitis
  • Symptomatic relief of acute gouty arthritis
  • Short-term treatment of moderate pain associated with dental surgery

Pharmacology

  • Potent, orally active cyclooxygenase-2 (COX-2) specific inhibitor
  • Decreases clinical signs and symptoms with decreased potential for gastrointestinal toxicity and effects on platelet aggregation

Dosage & Administration

  • Recommended dosage for Osteoarthritis: 30 mg once daily
  • Recommended dosage for Rheumatoid arthritis: 90 mg once daily
  • Recommended dosage for Ankylosing spondylitis: 90 mg once daily
  • Recommended dosage for Acute gouty arthritis: 120 mg once daily
  • Recommended dosage for postoperative dental surgery pain: 90 mg once daily, limited to a maximum of 3 days

Interaction

  • May interact with oral anticoagulants
  • May reduce the effect of diuretics and other antihypertensive drugs
  • Can be used concomitantly with low-dose acetylsalicylic acid
  • May increase the nephrotoxic effect of ciclosporin or tacrolimus
  • Decreases lithium renal excretion and therefore increase lithium plasma levels

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients
  • Active peptic ulceration or active gastrointestinal (GI) bleeding
  • Patients who have experienced allergic-type reactions after taking acetylsalicylic acid or NSAIDs including COX-2 inhibitors
  • Pregnancy and lactation
  • Severe hepatic dysfunction
  • Estimated renal creatinine clearance <30 ml/min
  • Inflammatory bowel disease
  • Congestive heart failure
  • Patients with hypertension whose blood pressure is persistently elevated above 140/90 mmHg
  • Established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease

Side Effects

  • Palpitation
  • Fatigue
  • Influenza-like symptoms
  • Ecchymosis
  • Dry mouth
  • Taste disturbance
  • Mouth ulcer
  • Appetite and weight change
  • Atrial fibrillation
  • Transient ischaemic attack
  • Chest pain
  • Flushing
  • Cough
  • Dyspnoea
  • Epistaxis
  • Anxiety
  • Mental acuity impaired
  • Paraesthesia
  • Electrolyte disturbance
  • Myalgia and arthralgia
  • Confusion
  • Hallucinations

Pregnancy & Lactation

  • Not recommended in women attempting to conceive
  • Not known whether excreted in human milk
  • Not recommended for breastfeeding women

Precautions & Warnings

  • Caution advised with treatment of patients at risk of developing gastrointestinal complications with NSAIDs
  • Caution in patients with significant risk factors for cardiovascular events
  • May cause reduction in prostaglandin formation and impaired renal function
  • Caution in patients with a history of cardiac failure, left ventricular dysfunction, or hypertension
  • Monitoring of renal function should be considered
  • Monitoring advised for patients with symptoms and/or signs suggesting liver dysfunction
  • Discontinue at the first appearance of skin rash or any other sign of hypersensitivity
  • May mask fever and other signs of inflammation

Overdose Effects

  • Single doses up to 500 mg and multiple doses up to 150 mg/day did not result in significant toxicity
  • Usual supportive measures should be employed in the event of overdose

Therapeutic Class

  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at a temperature of below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C18H15ClN2O2S

Common Questions about Cox-E 90 mg Tablet

  • Duration of effect lasts for an average duration of 20-24 hours
  • Onset of action can be observed within 1-2 hours of administration
  • Not recommended for pregnant women
  • Not habit forming
  • Unsafe to consume with alcohol
  • Affects alertness and should be avoided while driving
  • Caution needed in patients with kidney disease
  • Caution needed in patients with liver disease

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