Coxetori 120 mg (Tablet)

Unit Price: ৳ 12.00 (20's pack: ৳ 240.00)

Medicine Details

Category Details
Generic Etoricoxib
Company Amulet pharmaceuticals ltd
Also available as
Coxetori 60 mg tablet

Indications

  • Symptomatic relief of Osteoarthritis (OA)
  • Symptomatic relief of Rheumatoid arthritis (RA)
  • Symptomatic relief of Ankylosing spondylitis
  • Symptomatic relief of acute gouty arthritis
  • Short-term treatment of moderate pain associated with dental surgery

Pharmacology

  • Potent orally active cyclooxygenase-2 (COX-2) specific inhibitor
  • Inhibition of COX-2 decreases signs and symptoms of pain, inflammation, and fever
  • Decreased potential for gastrointestinal toxicity and effects on platelet aggregation

Dosage & Administration

  • Recommended dose for Osteoarthritis: 30 mg once daily, may increase to 60 mg once daily if insufficient relief
  • Recommended dose for Rheumatoid arthritis and Ankylosing spondylitis: 90 mg once daily
  • Recommended dose for Acute gouty arthritis: 120 mg once daily for 8 days
  • Recommended dose for Postoperative dental surgery pain: 90 mg once daily up to 3 days

Interaction

  • Increase in prothrombin time with oral anticoagulants
  • Reduction in effect of diuretics and other antihypertensive drugs with NSAIDs
  • Concomitant use with low-dose acetylsalicylic acid
  • Potential increase in nephrotoxic effect when coadministered with ciclosporin or tacrolimus
  • Decreased lithium renal excretion and increased lithium plasma levels with NSAIDs
  • Take without regards to meals

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Active peptic ulceration or gastrointestinal (GI) bleeding
  • History of allergic-type reactions to acetylsalicylic acid or NSAIDs
  • Pregnancy, lactation, severe hepatic dysfunction, estimated renal creatinine clearance <30 ml/min
  • Children and adolescents under 16 years of age
  • Inflammatory bowel disease, congestive heart failure, uncontrolled hypertension
  • Established ischaemic heart disease, peripheral arterial disease, cerebrovascular disease

Side Effects

  • Palpitation
  • Fatigue
  • Influenza-like symptoms
  • Ecchymosis
  • Dry mouth
  • Taste disturbance
  • Mouth ulcer
  • Atrial fibrillation
  • Transient ischaemic attack
  • Chest pain
  • Flushing
  • Cough
  • Dyspnoea
  • Epistaxis
  • Anxiety
  • Impaired mental acuity
  • Paraesthesia
  • Electrolyte disturbance
  • Myalgia
  • Arthralgia
  • Confusion
  • Hallucinations

Pregnancy & Lactation

  • Not recommended in women attempting to conceive
  • Excreted in the milk of lactating rats
  • Women using it must not breastfeed

Precautions & Warnings

  • Caution in patients at risk of developing gastrointestinal complications
  • Special consideration for patients with significant cardiovascular risk factors
  • Monitoring of renal function in patients with decreased prostaglandin formation
  • Caution in patients with history of cardiac failure, left ventricular dysfunction, hypertension, or edema
  • Monitoring of liver function and discontinuation upon signs of hepatic insufficiency
  • Discontinuation at first appearance of hypersensitivity signs
  • Caution when co-administering with warfarin or other oral anticoagulants

Overdose Effects

  • Single doses up to 500 mg and multiple doses up to 150 mg/day did not result in significant toxicity
  • Usual supportive measures may be employed in the event of overdose

Therapeutic Class

  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store below 30°C, protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C18H15ClN2O2S
  • Chemical Structure: https://medex.com.bd/storage/res/g-res-446-etoricoxib-chemical-structure-nEkDifKyFxQ9fjJEG7TQ.svg

Common Questions about Coxetori 120 mg Tablet

  • What is Coxetori 120 mg Tablet?: Selective COX-2 inhibitor primarily responsible for synthesis of prostanoid mediators of pain, inflammation, and fever
  • Duration of effect: 20-24 hours
  • Onset of action: Within 1-2 hours of administration, faster if taken without food
  • Pregnancy warnings: Not recommended; consult doctor before use
  • Habit forming: No
  • Breast-feeding warnings: Not recommended; potential benefits vs. risks
  • Safety with alcohol: Unsafe
  • Safety to drive while on this medicine: May affect alertness; avoid driving
  • Effect on kidney function: Caution in patients with kidney disease; strict avoidance in severe cases
  • Effect on liver function: Caution in patients with liver disease; strict avoidance in severe cases
  • Quick Tips:
    • Helps relieve pain and inflammation
    • May cause fewer stomach problems than other NSAIDs
    • May cause dizziness and fatigue; avoid activities requiring concentration
    • Avoid alcohol consumption
    • Monitor blood pressure regularly
    • Inform doctor of relevant medical history
    • Regular liver function tests during long-term treatment
    • Avoid if pregnant, planning to conceive, or breastfeeding

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