Etorgin 120 mg (Tablet)
Unit Price: ৳ 14.00 (30's pack: ৳ 420.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Etoricoxib |
| Company | Cosmic pharma ltd |
| Also available as |
Indications
- Symptomatic relief of Osteoarthritis (OA)
- Symptomatic relief of Rheumatoid arthritis (RA)
- Symptomatic relief of Ankylosing spondylitis
- Symptomatic relief of acute gouty arthritis
- Short-term treatment of moderate pain associated with dental surgery
Pharmacological Actions
- Potent COX-2 specific inhibitor
- Inhibition of prostaglandin-mediated pain, inflammation, and fever
- Decreases signs and symptoms of inflammation
- Selective inhibition of COX-2 within clinical dose range
- Decreased potential for gastric toxicity and effects on platelet aggregation
Dosage and Administration
- Recommended dose for Osteoarthritis: 30 mg once daily
- Recommended dose for Rheumatoid arthritis: 90 mg once daily
- Recommended dose for Ankylosing spondylitis: 90 mg once daily
- Recommended dose for Acute gouty arthritis: 120 mg once daily (for 8 days)
- Recommended dose for Postoperative dental surgery pain: 90 mg once daily (up to 3 days)
Interactions
- Increase in prothrombin time with oral anticoagulants
- Potential reduction in effect of diuretics and antihypertensive drugs
- Concomitant use with low-dose acetylsalicylic acid
- Potential increase in nephrotoxic effect when coadministered with ciclosporin or tacrolimus
- Decreased lithium renal excretion leading to increased lithium plasma levels
Contraindications
- Hypersensitivity to the active substance or excipients
- Active peptic ulceration or gastrointestinal (GI) bleeding
- History of allergic-type reactions to acetylsalicylic acid or NSAIDs
- Pregnancy and lactation
- Severe hepatic dysfunction
- Estimated renal creatinine clearance <30 ml/min
- Children and adolescents under 16 years of age
- Inflammatory bowel disease
- Congestive heart failure (NYHA ll-IV)
- Persistently elevated blood pressure above 140/90 mmHg
- Established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
Side Effects
- Palpitation
- Fatigue
- Influenza-like symptoms
- Ecchymosis
- Dry mouth
- Taste disturbance
- Mouth ulcer
- Atrial fibrillation
- Transient ischaemic attack
- Chest pain
- Flushing
- Cough
- Dyspnoea
- Epistaxis
- Anxiety
- Impaired mental acuity
- Paraesthesia
- Electrolyte disturbance
- Myalgia
- Arthralgia
- Confusion
- Hallucinations
Pregnancy and Lactation
- Not recommended in women attempting to conceive
- Not recommended for breastfeeding women
Precautions and Warnings
- Caution in patients at risk of gastrointestinal complications with NSAIDs
- Careful consideration for patients with significant cardiovascular risk factors
- Monitor renal function in patients with potential impairment
- Exercise caution in patients with cardiac failure, left ventricular dysfunction, or hypertension
- Monitor for signs of hepatic insufficiency
- Discontinue at the first appearance of hypersensitivity signs
- May mask fever and other signs of inflammation
- Exercise caution when co-administering with oral anticoagulants
Overdose Effects
- No significant toxicity observed with single doses up to 500 mg and multiple doses up to 150 mg/day for 21 days
- Employ usual supportive measures in case of overdose
Therapeutic Class
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Store below 30°C
- Protect from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C18H15ClN2O2S
Duration of Effect
- Average duration of 20-24 hours
Onset of Action
- Onset within 1-2 hours of administration, faster if taken without food
Pregnancy Warnings
- Consult doctor before use in pregnancy
Habit Forming Tendencies
- No habit-forming tendencies reported
Breastfeeding Warnings
- Not recommended for breastfeeding mothers
Safety with Alcohol
- Unsafe to consume with alcohol
Effect on Driving
- May affect alertness, avoid driving
Effect on Kidney Function
- Caution in patients with kidney disease, adjustment of dose might be needed
Effect on Liver Function
- Caution in patients with liver disease, adjustment of dose might be needed
Quick Tips
- Helps relieve pain and inflammation
- May cause fewer stomach problems compared to other NSAIDs like Ibuprofen or Naproxen
- May cause dizziness and fatigue, avoid activities requiring concentration
- Do not consume alcohol during treatment
- Regularly monitor blood pressure during initial treatment
- Inform doctor of history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease
- May require regular blood tests for liver function during long-term treatment
- Not recommended in pregnancy, planning to conceive, or breastfeeding