Etorix 120 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Etoricoxib |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Symptomatic relief of osteoarthritis (OA)
- Symptomatic relief of rheumatoid arthritis (RA)
- Symptomatic relief of ankylosing spondylitis
- Symptomatic relief of acute gouty arthritis
- Short-term treatment of moderate pain associated with dental surgery
Pharmacology
- Potent, orally active cyclooxygenase-2 (COX-2) specific inhibitor
- Inhibits COX-2 without affecting COX-1
- Decreases clinical signs and symptoms of pain, inflammation, and fever
- Decreases potential for GI toxicity and effects on platelet aggregation
- Dose-dependent inhibition of COX-2 without inhibition of COX-1 at doses up to 150 mg daily
Dosage and administration
- Recommended doses for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gouty arthritis, and postoperative dental surgery pain
- Potential need for increased dose for insufficient relief from symptoms in some patients
- Consideration of cardiovascular risks with dose and duration of exposure
- Periodic re-evaluation of patient's need for symptomatic relief and response to therapy
Interactions
- Potential interaction with oral anticoagulants
- Possible reduction of effect of diuretics and antihypertensive drugs
- Concomitant use with low-dose acetylsalicylic acid for cardiovascular prophylaxis
- Potential increase in nephrotoxic effect of ciclosporin or tacrolimus
- Decreased lithium renal excretion leading to increased plasma levels
Contraindications
- Hypersensitivity to the active substance or excipients
- Active peptic ulceration or active gastrointestinal (GI) bleeding
- History of allergic-type reactions after taking acetylsalicylic acid or NSAIDs
- Pregnancy and lactation
- Severe hepatic dysfunction
- Estimated renal creatinine clearance < 30 ml/min
- Inflammatory bowel disease
- Congestive heart failure (NYHA ll-IV)
- Uncontrolled hypertension
- Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
Side effects
- Palpitation
- Fatigue
- Influenza-like symptoms
- Ecchymosis
- Dry mouth
- Taste disturbance
- Atrial fibrillation
- Chest pain
- Anxiety
- Myalgia
- Arthralgia
- Confusion
- Hallucinations
Pregnancy and lactation
- Not recommended in women attempting to conceive
- Unknown excretion in human milk
- Excreted in the milk of lactating rats
Precautions and warnings
- Caution in patients at risk of developing gastrointestinal complications with NSAIDs
- Caution in patients with significant risk factors for cardiovascular events
- Monitoring of renal function in patients with reduced prostaglandin formation and impaired renal blood flow
- Caution in patients with history of cardiac failure, left ventricular dysfunction, hypertension, or pre-existing edema
- Monitoring of liver function and discontinuation if signs of hepatic insufficiency occur
- Discontinuation at first appearance of skin rash, mucosal lesions, or signs of hypersensitivity
- Potential mask of fever and other signs of inflammation
- Caution when co-administering with warfarin or other oral anticoagulants
Overdose effects
- No significant toxicity observed with single doses up to 500 mg and multiple doses up to 150 mg/day for 21 days
- Employment of usual supportive measures in the event of overdose
Therapeutic class
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage conditions
- Store below 30°C
- Protect from light and moisture
- Keep out of reach of children
Chemical structure
- Molecular formula: C18H15ClN2O2S
- Chemical structure image available
Common questions
- Duration of effect
- Onset of action
- Pregnancy warnings
- Habit forming tendencies
- Breast-feeding warnings
- Safety with alcohol
- Safety to drive while on medication
- Effect on kidney function
- Effect on liver function
- Quick tips for usage