Kingcox 60 mg (Tablet)

Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)

Strip Price: ৳ 70.00

Medicine Details

Category	Details
Generic	Etoricoxib
Company	Medicon pharmaceuticals ltd
Also available as	Kingcox 90 mg tablet

Title

Kingcox 60 mg Tablet

Indications

Osteoarthritis (OA)
Rheumatoid arthritis (RA)
Ankylosing spondylitis
Acute gouty arthritis
Moderate pain associated with dental surgery

Pharmacology

Potent COX-2 specific inhibitor
Inhibition of COX-2 decreases pain, inflammation, and fever
Selective COX-2 inhibition
No inhibition of COX-1 at clinical doses

Dosage & Administration

30 mg once daily for OA (increased to 60 mg if insufficient relief)
90 mg once daily for RA and ankylosing spondylitis
120 mg once daily for acute gouty arthritis
90 mg once daily for postoperative dental surgery pain (up to 3 days)
Shortest duration and lowest effective dose recommended

Interactions

Increases prothrombin time with oral anticoagulants
May reduce the effect of diuretics and antihypertensive drugs
Concomitant use with low-dose acetylsalicylic acid permissible
Possible increase in nephrotoxic effect with ciclosporin or tacrolimus
Decreases lithium renal excretion and increases plasma levels

Contraindications

Hypersensitivity to active substance or excipients
Active peptic ulceration or gastrointestinal bleeding
Bronchospasm or allergic-type reactions to NSAIDs
Pregnancy, lactation, severe hepatic dysfunction, estimated renal clearance <30 ml/min, under 16 years of age, inflammatory bowel disease, congestive heart failure, uncontrolled hypertension, established cardiovascular diseases

Side Effects

Palpitation
Fatigue
Influenza-like symptoms
Ecchymosis
Dry mouth
Taste disturbance
Appetite and weight change
Atrial fibrillation
Transient ischemic attack
Chest pain
Flushing
Cough
Dyspnoea
Epistaxis
Anxiety
Impaired mental acuity
Paraesthesia
Electrolyte disturbance
Myalgia
Arthralgia
Confusion
Hallucinations

Pregnancy & Lactation

Not recommended for women attempting to conceive
Excreted in rat milk
Breastfeeding not recommended

Precautions & Warnings

Caution in patients at risk for gastrointestinal complications with NSAIDs
Consideration for patients with significant cardiovascular risk factors
May impair renal function and blood flow in susceptible patients
Exercise caution in patients with history of cardiac failure, edema, or liver dysfunction
Discontinue at signs of hypersensitivity or hepatic insufficiency
May mask fever and signs of inflammation

Overdose Effects

Single doses up to 500 mg and multiple doses up to 150 mg/day did not result in significant toxicity
Employ usual supportive measures in case of overdose

Therapeutic Class

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store below 30°C
Protect from light and moisture
Keep out of reach of children

Chemical Structure

Molecular Formula: C18H15ClN2O2S

Duration of Effect

20-24 hours

Onset of Action

1-2 hours, faster if taken without food

Pregnancy Warnings

Consult doctor before use

Habit Forming

Breastfeeding Warnings

Not recommended, consult doctor before use

Alcohol Interaction

Unsafe

Safe to Drive

May affect alertness, avoid driving

Kidney Function

Caution in patients with kidney disease, dose adjustment may be needed

Liver Function

Caution in patients with liver disease, dose adjustment may be needed

Quick Tips

Relieves pain and inflammation
May cause fewer stomach problems compared to other NSAIDs
May cause dizziness and fatigue
Avoid alcohol consumption
Regularly monitor blood pressure
Inform doctor of medical history
Regular blood tests may be required