Astin 10 mg (Tablet)

Unit Price: ৳ 8.06 (3 x 10: ৳ 241.80)

Strip Price: ৳ 80.60

Medicine Details

Category	Details
Generic	Atorvastatin calcium
Company	Jayson pharmaceuticals ltd
Also available as	Astin 20 mg tablet

Title

Astin 10 mg Tablet

Description

Astin 10 mg Tablet is used as an adjunct to diet to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels in various conditions such as familial hypercholesterolaemia, mixed dyslipidemia, hypertriglyceridaemia, dysbetalipoproteinaemia, coronary artery disease, and hypercholesterolemia associated with diabetes mellitus or renal transplantation.

DosageAndAdministration

Adults: Usually 10 mg once daily; may be increased to max. 80 mg once daily if necessary.
Child (10-18 years): Initially 10 mg once daily, increased to max. 20 mg once daily if necessary.
It should be administered as a single dose at any time of the day, with or without food.

Pharmacology

Absorption: Rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours.
Distribution: Mean volume of distribution is approximately 381 liters; 98% bound to plasma proteins.
Metabolism: Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products.
Excretion: Primarily eliminated in bile following hepatic and/or extra-hepatic metabolism.

Interaction

Increased risk of myopathy with concurrent administration of cyclosporine, fibric acid derivatives, niacin, erythromycin, and azole antifungals.
Plasma concentrations decreased when coadministered with antacid and increased when coadministered with oral contraceptives.

Contraindications

Hypersensitivity to any component of the medication
Active liver disease or unexplained persistent elevations of serum transaminases
History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

SideEffects

Constipation
Flatulence
Dyspepsia
Abdominal pain
Infection
Headache
Back pain
Rash
Asthenia
Arthralgia
Myalgia

PregnancyAndLactation

Pregnancy: Contraindicated during pregnancy
Lactation: Atorvastatin is not recommended for breastfeeding women due to the potential for serious adverse reactions.

PrecautionsAndWarnings

Liver function tests should be performed before and periodically during treatment; therapy should be discontinued if markedly elevated CPK levels occur or myopathy is diagnosed or suspected.

SpecialPopulations

Geriatric: Plasma concentrations are higher in elderly subjects than in young adults.
Pediatric: Pharmacokinetic data in the pediatric population are not available.
RenalInsufficiency: No influence on plasma concentrations or LDL-C reduction.
HepaticInsufficiency: Plasma concentrations are markedly increased in patients with chronic alcoholic liver disease.

OverdoseEffects

Specific treatment is not available; patient should be treated symptomatically and supportive measures instituted, as required.

TherapeuticClass

Other Anti-anginal & Anti-ischaemic drugs
Statins

StorageConditions

Keep in a dry place away from light and heat; keep out of the reach of children.

ChemicalStructure

MolecularFormula: C33H35FN2O5
ChemicalStructureImage: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg

FrequentlyAskedQuestions

WhatIsAstin10mgTablet: A selective inhibitor of HMG-CoA reductase used to avoid heart attacks and treat conditions such as Mixed Dyslipidemia and Hypertriglyceridemia.
HowToTakeAstin10mgTablet: Should be taken by mouth once daily, at the same time each day, with or without food.
SideEffectsOfAstin10mgTablet: Possible side-effects include cough, muscle pain, breathing difficulty, and running nose.
InstructionsForStorageAndDisposal: Should be stored at room temperature, away from heat and direct light, and kept away from the reach of children and pets.
IsAstin10mgTabletUsedForLoweringCholesterol: Yes, it is used to lower cholesterol and triglycerides present in the blood, and should be taken with a cholesterol-lowering diet.