Setorib 60 mg (Tablet)

Unit Price: ৳ 7.04 (4 x 10: ৳ 281.60)
Strip Price: ৳ 70.40

Medicine Details

Category Details
Generic Etoricoxib
Company Acme laboratories ltd
Also available as
Setorib 90 mg tablet Setorib 120 mg tablet

Indications

  • Symptomatic relief of Osteoarthritis (OA)
  • Symptomatic relief of Rheumatoid arthritis (RA)
  • Symptomatic relief of Ankylosing spondylitis
  • Symptomatic relief of acute gouty arthritis
  • Short-term treatment of moderate pain associated with dental surgery

Pharmacology

  • Potent, orally active cyclooxygenase-2 (COX-2) specific inhibitor
  • Inhibition of COX-2 decreases clinical signs and symptoms
  • Selective inhibition of COX-2 with decreased potential for GI toxicity and effects on platelet aggregation

Dosage & Administration

  • Recommended dose for Osteoarthritis: 30 mg once daily, may increase to 60 mg once daily
  • Recommended dose for Rheumatoid arthritis: 90 mg once daily
  • Recommended dose for Ankylosing spondylitis: 90 mg once daily
  • Recommended dose for Acute gouty arthritis: 120 mg once daily
  • Recommended dose for Postoperative dental surgery pain: 90 mg once daily, limited to a maximum of 3 days

Interaction

  • Interaction with oral anticoagulants leading to increase in prothrombin time
  • Potential reduction in the effect of diuretics and other antihypertensive drugs when taken concomitantly
  • Can be used concomitantly with low-dose acetylsalicylic acid for cardiovascular prophylaxis
  • Potential increase in nephrotoxic effect of ciclosporin or tacrolimus when coadministered with NSAIDs
  • NSAIDs decrease lithium renal excretion and increase lithium plasma levels

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Active peptic ulceration or active gastrointestinal (GI) bleeding
  • Patients who have experienced bronchospasm or allergic-type reactions after taking acetylsalicylic acid or NSAIDs
  • Pregnancy and lactation
  • Severe hepatic dysfunction, estimated renal creatinine clearance <30 ml/min, children and adolescents under 16 years of age, inflammatory bowel disease, congestive heart failure, uncontrolled hypertension, established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease

Side Effects

  • Palpitation
  • Fatigue
  • Influenza-like symptoms
  • Ecchymosis
  • Dry mouth
  • Taste disturbance
  • Mouth ulcer
  • Atrial fibrillation
  • Transient ischaemic attack
  • Chest pain
  • Flushing
  • Cough
  • Dyspnoea
  • Epistaxis
  • Anxiety
  • Impaired mental acuity
  • Paraesthesia
  • Electrolyte disturbance
  • Myalgia
  • Arthralgia
  • Confusion
  • Hallucinations

Pregnancy & Lactation

  • Not recommended in women attempting to conceive
  • Not known whether excreted in human milk
  • Excreted in the milk of lactating rats
  • Women who use it must not breastfeed

Precautions & Warnings

  • Caution with patients at risk of developing gastrointestinal complications
  • Caution with patients having significant risk factors for cardiovascular events
  • May cause reduction in prostaglandin formation and impair renal function
  • Caution in patients with a history of cardiac failure, left ventricular dysfunction, or hypertension
  • Monitoring of renal function and liver function tests recommended
  • Discontinue at the first appearance of hypersensitivity signs
  • May mask fever and other signs of inflammation
  • Caution when co-administering with warfarin or other oral anticoagulants

Overdose Effects

  • Single doses up to 500 mg and multiple doses up to 150 mg/day did not result in significant toxicity
  • Usual supportive measures may be employed in case of overdose

Therapeutic Class

  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at a temperature below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C18H15ClN2O2S
  • Chemical Structure: Image (can be referred from source)

Common Questions about Setorib 60 mg Tablet

  • Selective COX-2 inhibitor for pain, inflammation, and fever relief
  • Indicated for Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis
  • Duration of effect: 20-24 hours
  • Onset of action: 1-2 hours, faster if taken without food
  • Not recommended for women attempting to conceive or breastfeeding
  • No habit-forming tendencies reported
  • Unsafe to consume with alcohol
  • May affect alertness, hence avoid driving
  • Caution in patients with kidney disease or liver disease
  • Quick tips for usage and precautions

Related Brands