Setorib 90 mg (Tablet)
Unit Price: ৳ 12.09 (3 x 10: ৳ 362.70)
Strip Price: ৳ 120.90
Medicine Details
| Category | Details |
|---|---|
| Generic | Etoricoxib |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Osteoarthritis (OA)
- Rheumatoid arthritis (RA)
- Ankylosing spondylitis
- Acute gouty arthritis
- Moderate pain associated with dental surgery
Pharmacology
- Orally active cyclooxygenase-2 (COX-2) specific inhibitor
- Inhibition of COX-2 for pain, inflammation, and fever relief
- Potent within clinical dose range
- Decreased potential for gastrointestinal toxicity and effects on platelet aggregation
Dosage & Administration
- Recommended doses for different conditions
- Increase in dose for insufficient relief
- Short-term treatment for dental surgery pain
- Consideration of cardiovascular risks with dose and duration
- Re-evaluation of patient's need for relief
Interaction
- Effects with oral anticoagulants
- Reduction of diuretic and antihypertensive drugs' effect
- Concomitant use with low-dose acetylsalicylic acid
- Possible increase in nephrotoxic effect with ciclosporin or tacrolimus
- Decreased lithium excretion and increased plasma levels
Contraindications
- Hypersensitivity to active substance or excipients
- Active peptic ulceration or gastrointestinal bleeding
- History of allergic-type reactions to NSAIDs
- Pregnancy, lactation, severe hepatic dysfunction, or estimated renal creatinine clearance <30 ml/min
- Children and adolescents under 16 years of age
- Inflammatory bowel disease, congestive heart failure, uncontrolled hypertension, and established ischemic heart disease
Side Effects
- Palpitation, fatigue, influenza-like symptoms
- Ecchymosis, dry mouth, taste disturbance
- Atrial fibrillation, transient ischemic attack, chest pain
- Anxiety, impaired mental acuity, paraesthesia
- Electrolyte disturbance, myalgia, arthralgia
- Rarely confusion and hallucinations
Pregnancy & Lactation
- Not recommended for women attempting to conceive
- Excretion in lactating rats, thus not recommended for breastfeeding mothers
Precautions & Warnings
- Caution with patients at risk of gastrointestinal complications
- Consideration for patients with significant cardiovascular risk factors
- Monitoring of renal function in certain patients
- Exercise caution in patients with history of cardiac failure, left ventricular dysfunction, or hypertension
- Monitoring and possible discontinuation in case of liver dysfunction or signs of hypersensitivity
- Potential masking of fever and inflammation signs
- Use with caution when co-administering with oral anticoagulants
Overdose Effects
- Lack of significant toxicity with single and multiple doses up to a certain level
- Employment of usual supportive measures in the event of overdose
Therapeutic Class
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Temperature below 30°C, protection from light and moisture, keep out of reach of children
Chemical Structure
- Molecular Formula: C18H15ClN2O2S
Duration of Effect
20-24 hours
Onset of Action
Within 1-2 hours of administration
Pregnancy Warnings
Consultation required for pregnant women
Habit Forming
Not reported
Breast-feeding Warnings
Not recommended, consultation required
Safety with Alcohol
Unsafe to consume with alcohol
Safety to Drive
May affect alertness, thus driving should be avoided
Effect on Kidney Function
Caution required for patients with kidney disease
Effect on Liver Function
Caution required for patients with liver disease
Quick Tips
- Relieves pain and inflammation
- May cause fewer stomach problems compared to other NSAIDs
- May cause dizziness and fatigue
- Avoid consumption with alcohol
- Regular blood pressure monitoring recommended
- Inform doctor of relevant medical history
- Regular liver function tests during long-term treatment
- Not recommended for pregnant, planning to conceive, or breastfeeding women