Coxsafe 90 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)

Strip Price: ৳ 120.00

Medicine Details

Category	Details
Generic	Etoricoxib
Company	Sharif pharmaceuticals ltd
Also available as	Coxsafe 60 mg tablet Coxsafe 120 mg tablet

Symptomatic relief of Osteoarthritis (OA)
Symptomatic relief of Rheumatoid arthritis (RA)
Symptomatic relief of Ankylosing spondylitis
Symptomatic relief of pain and signs of inflammation associated with acute gouty arthritis
Short-term treatment of moderate pain associated with dental surgery

Potent, orally active cyclooxygenase-2 (COX-2) specific inhibitor
Inhibition of COX-2 decreases clinical signs and symptoms
Selective inhibition of COX-2 decreases potential for GI toxicity and effects on platelet aggregation
Did not inhibit gastric prostaglandin synthesis
Decreases potential for GI toxicity and effects on platelet aggregation

Recommended adult dose for Osteoarthritis: 30 mg once daily (60 mg once daily in some cases)
Recommended adult dose for Rheumatoid arthritis: 90 mg once daily
Recommended adult dose for Ankylosing spondylitis: 90 mg once daily
Recommended adult dose for Acute gouty arthritis: 120 mg once daily for 8 days
Recommended adult dose for Postoperative dental surgery pain: 90 mg once daily for maximum of 3 days
Shortest duration possible and lowest effective daily dose should be used

Increase in prothrombin time when administered with oral anticoagulants
May reduce the effect of diuretics and other antihypertensive drugs when administered with diuretics, ACE inhibitors, and Angiotensin II Antagonists
Can be used concomitantly with low-dose acetylsalicylic acid for cardiovascular prophylaxis
Coadministration with ciclosporin or tacrolimus may increase nephrotoxic effect
Decreases lithium renal excretion and increases lithium plasma levels when administered with lithium

Hypersensitivity to active substance or excipients
Active peptic ulceration or active gastrointestinal (GI) bleeding
Patients with bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria, or allergic-type reactions after taking acetylsalicylic acid or NSAIDs
Pregnancy and lactation
Severe hepatic dysfunction
Estimated renal creatinine clearance <30 ml/min
Children and adolescents under 16 years of age
Inflammatory bowel disease
Congestive heart failure (NYHA ll-IV)
Uncontrolled hypertension, established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease

Caution advised for patients at risk of developing gastrointestinal complication with NSAIDs
Caution in patients with significant risk factors for cardiovascular events
Monitoring of renal function in patients with reduced prostaglandin formation and impaired renal function
Caution in patients with history of cardiac failure, left ventricular dysfunction, or hypertension
Monitoring advised for signs of hepatic insufficiency
Discontinue at first appearance of hypersensitivity reactions
May mask fever and other signs of inflammation, caution with co-administration with oral anticoagulants

Single doses up to 500 mg and multiple doses up to 150 mg/day did not result in significant toxicity
Usual supportive measures recommended in the event of overdose

Selective COX-2 inhibitor responsible for synthesis of prostanoid mediators of pain, inflammation, and fever
Indicated for symptomatic relief of Osteoarthritis (OA), Rheumatoid arthritis (RA), Ankylosing spondylitis
Duration of effect: 20-24 hours
Onset of action within 1-2 hours of administration
Not recommended for pregnant or breastfeeding women
Not habit forming
Unsafe to consume with alcohol
May affect patient alertness, thus avoid driving
Caution in patients with kidney or liver disease
Regular blood pressure monitoring recommended