Coxsafe 120 mg (Tablet)
Unit Price: ৳ 14.00 (2 x 10: ৳ 280.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Etoricoxib |
| Company | Sharif pharmaceuticals ltd |
| Also available as |
Indications
- Osteoarthritis (OA)
- Rheumatoid arthritis (RA)
- Ankylosing spondylitis
- Acute gouty arthritis
- Moderate pain associated with dental surgery
Pharmacology
- Potent, orally active COX-2 specific inhibitor
- Inhibition of COX-2 decreases clinical signs and symptoms
- Selective inhibition of COX-2 decreases potential for GI toxicity
- Did not inhibit gastric prostaglandin synthesis
Dosage & Administration
- Recommended doses for different conditions
- Shortest duration and lowest effective daily dose usage
- Need for re-evaluation periodically
Interaction
- Interaction with oral anticoagulants
- Effect on diuretics and antihypertensive drugs
- Concomitant use with acetylsalicylic acid
- Possible nephrotoxic effect with ciclosporin or tacrolimus
- Increase in lithium plasma levels
Contraindications
- Hypersensitivity to active substance or excipients
- Active peptic ulceration or GI bleeding
- Bronchospasm, acute rhinitis, nasal polyps, allergic-type reactions after taking NSAIDs
- Pregnancy and lactation
- Severe hepatic dysfunction
- Estimated renal creatinine clearance <30 ml/min
- Inflammatory bowel disease
- Congestive heart failure
- Hypertension not adequately controlled
- Established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
Side Effects
- Palpitation
- Fatigue
- Influenza-like symptoms
- Ecchymosis
- Dry mouth
- Taste disturbance
- Mouth ulcer
- Atrial fibrillation
- Chest pain
- Flushing
- Cough
- Dyspnoea
- Epistaxis
- Anxiety
- Paraesthesia
- Electrolyte disturbance
- Myalgia
- Arthralgia
- Confusion
- Hallucinations
Pregnancy & Lactation
- Not recommended in women attempting to conceive
- Not recommended for breastfeeding mothers
Precautions & Warnings
- Caution with patients at risk of GI complications with NSAIDs
- Caution with patients at risk of cardiovascular events
- Possible reduction in renal blood flow
- Caution in patients with history of cardiac failure, left ventricular dysfunction, or hypertension
- Monitoring of renal and liver function
- Discontinuation at first appearance of hypersensitivity signs
- Caution when co-administering with warfarin or other oral anticoagulants
Overdose Effects
- No significant toxicity observed even at high doses
- Employment of usual supportive measures in case of overdose
Therapeutic Class
- NSAIDs
Storage Conditions
- Temperature below 30°C
- Protection from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C18H15ClN2O2S
- Chemical Structure Image URL
Common Questions about Coxsafe 120 mg Tablet
- What is Coxsafe 120 mg Tablet: Selective COX-2 inhibitor for symptomatic relief of pain, inflammation, and fever
- Uses of Coxsafe 120 mg Tablet: Symptomatic relief of Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis
- Duration of effect of Coxsafe 120 mg Tablet: Average duration of 20-24 hours
- Onset of action of Coxsafe 120 mg Tablet: Can be observed within 1-2 hours of administration
- Pregnancy warnings of Coxsafe 120 mg Tablet: Not recommended for pregnant women
- Habit forming of Coxsafe 120 mg Tablet: No habit-forming tendencies reported
- Breast-feeding warnings of Coxsafe 120 mg Tablet: Not recommended for breastfeeding mothers
- Safe usage with alcohol: Unsafe to consume with alcohol
- Safe to drive while on this medicine: May affect alertness, patient must avoid driving
- Effect on kidney function: Caution in patient with kidney disease
- Effect on liver function: Caution in patient with liver disease
- Quick Tips:
- Helps relieve pain and inflammation
- May cause fewer stomach problems compared to other NSAIDs
- May cause dizziness and fatigue
- Do not consume with alcohol
- Regular blood pressure monitoring
- Inform doctor about medical history before usage
- Regular liver function tests during long-term treatment
- Avoid if pregnant, planning to conceive, or breastfeeding