Atasin 40 mg (Tablet)
Unit Price: ৳ 28.00 (3 x 10: ৳ 840.00)
Strip Price: ৳ 280.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Aci limited |
| Also available as |
Title
- Atasin 40 mg Tablet
Categories
- Medicine
- Healthcare
- Pharmaceutical
Description
- Atasin is indicated as an adjunct to diet to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels. It is a selective inhibitor of HMG-CoA reductase, lowering plasma cholesterol and lipoprotein levels. It is used to prevent heart attacks, treat conditions such as Mixed Dyslipidemia and Hypertriglyceridemia.
Dosage
- Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to max. 80 mg once daily.
Administration
- Take by mouth once daily, at the same time each day. Can be taken with or without food.
Primary Hypercholesterolaemia and Combined Hyperlipidaemia Dosage
- Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 20 mg once daily.
Familial Hypercholesterolaemia Dosage
- Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 80 mg once daily.
Prevention of Cardiovascular Events Dosage
- Initially 10 mg once daily, adjusted according to response.
Another Guideline
- The patient should be placed on a standard cholesterol-lowering diet before receiving Atorvastatin and should continue on this diet during treatment with Atorvastatin. The recommended starting dose of Atorvastatin is 10 or 20 mg once daily.
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy
- Contraindicated during pregnancy.
Lactation
- Atorvastatin or its metabolites are contraindicated during breastfeeding.
Precautions
- Liver function tests should be performed before the initiation of treatment and periodically thereafter.
Interaction
- Risk of myopathy is increased with concurrent administration of cyclosporine, fibric acid derivatives, niacin (nicotinic acid), erythromycin, azole antifungals.
Contraindications
- Hypersensitivity to any component of this medication
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Pharmacology
- Selective inhibitor of HMG-CoA reductase
- Absorption within 1 to 2 hours
- Distribution with mean volume of approximately 381 liters
- Metabolism by cytochrome P450 3A4
- Excretion primarily in bile
Storage Conditions
- Keep in a dry place away from light and heat. Keep out of the reach of children.
Chemical Structure
- Molecular Formula: C33H35FN2O5
- Chemical Structure image available
Common Questions
- Atorvastatin 40 mg Tablet is a selective inhibitor of HMG-CoA reductase
- How to take Atorvastatin 40 mg Tablet
- Side effects of Atorvastatin 40 mg Tablet
- Storage and disposal instructions for Atorvastatin 40 mg Tablet
- Atorvastatin 40 mg Tablet causes a lowering cholesterol
- Risk of diabetes with Atorvastatin 40 mg Tablet
- Duration and safety of Atorvastatin 40 mg Tablet use
- Weight loss and memory loss effects of Atorvastatin 40 mg Tablet
- Safety in children and blood thinning effect of Atorvastatin 40 mg Tablet
Use in Special Populations
- Higher plasma concentrations in healthy elderly subjects
- No clinically significant difference in LDL-C reduction between genders
- Renal disease has no influence on the plasma concentrations or LDL-C reduction
- Hepatic insufficiency leads to markedly increased plasma concentrations
Overdose Effects
- Specific treatment not available
- Symptomatic treatment and supportive measures required
- Monitor liver function tests and serum CK levels
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Precautions & Warnings
- Discontinue if markedly elevated CPK levels occur or myopathy is diagnosed or suspected
Mode of Action
- Selective inhibitor of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels
- Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL
Absorption
- Rapidly absorbed after oral administration
- Maximum plasma concentrations occur within 1 to 2 hours
Distribution
- Mean volume of distribution approximately 381 liters
- 98% bound to plasma proteins
- Likely to be secreted in human milk
Metabolism
- Extensively metabolized to ortho- and parahydroxylated derivatives
- Importance of metabolism by cytochrome P450 3A4
- Ortho-hydroxy metabolite undergoes further glucuronidation
Excretion
- Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism
- Mean plasma elimination half-life in humans approximately 14 hours
Interaction Details
- Antacid coadministration decreases plasma concentrations of Atorvastatin
- Increased LDL-C reduction with coadministration of Atorvastatin and colestipol
- Steady-state plasma digoxin concentrations increased by approximately 20% with coadministration of atorvastatin and digoxin
- Plasma concentrations of Atorvastatin increased approximately 40% with coadministration of Atorvastatin and erythromycin
- Increased AUC values for norethindrone and ethinyl estradiol by approximately 30% and 20% with coadministration of Atorvastatin and an oral contraceptive
- No clinically significant effect on prothrombin time
Pregnancy & Lactation
- Contraindicated during pregnancy and breastfeeding
- May reduce fetal levels of mevalonate
- Plasma concentrations of Atorvastatin and its active metabolites similar to those in milk
Chemical Structure Details
- Molecular Formula: C33H35FN2O5
- Chemical Structure image available