Atova 20 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Title
Atova 20 mg Tablet
Categories
- Medicine
- Pharmaceutical
Description
Atova is a selective inhibitor of HMG-CoA reductase used to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels.
Dosage
10 mg to 80 mg once daily for adults; 10 mg to 20 mg once daily for children (10-18 years)
Indications
- Reduce total cholesterol and LDL cholesterol
- Reduce elevated cholesterol and triglycerides
- Treatment of patients with elevated serum triglyceride levels
- Reduce cardiac ischemic events in patients with coronary artery disease
Mode of Action
Inhibits HMG-CoA reductase and cholesterol synthesis, increases hepatic LDL receptors
Absorption
Rapidly absorbed, maximum plasma concentrations within 1 to 2 hours
Distribution
Mean volume of distribution is approximately 381 liters, 98% bound to plasma proteins
Metabolism
Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products
Excretion
Eliminated primarily in bile, with a plasma elimination half-life of approximately 14 hours
Interaction
- Cyclosporine
- Fibric acid derivatives
- Niacin
- Erythromycin
- Azole antifungals
- Antacid
- Colestipol
- Digoxin
- Oral Contraceptives
- Warfarin
Contraindications
- Hypersensitivity to any component
- Active liver disease
- Unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy & Lactation
- Contraindicated during pregnancy
- Not known whether excreted in human milk, contraindicated during breastfeeding
Precautions & Warnings
Liver function tests should be performed before initiation of treatment and periodically thereafter
Use in Special Populations
- Higher plasma concentrations in elderly subjects
- No clinically significant difference in LDL-C reduction between men and women
Overdose Effects
Specific treatment is not available for atorvastatin overdose, patient should be treated symptomatically
Therapeutic Class
Other Anti-anginal & Anti-ischaemic drugs, Statins
Storage Conditions
Keep in a dry place away from light and heat, keep out of the reach of children
Chemical Structure
- Molecular Formula: C33H35FN2O5
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg
Common Questions
- What is Atova 20 mg Tablet?: Selective inhibitor of HMG-CoA reductase, used for avoiding heart attacks and treating hypercholesterolemia.
- How should I take Atova 20 mg Tablet?: Take it orally once daily, at the same time each day, with or without food.
- What are the uses of Atova 20 mg Tablet?: Treatment of mixed dyslipidemia, hypertriglyceridemia, and heart attacks.
- What are the Side Effects of Atova 20 mg Tablet?: Possible side-effects may include cough, muscle pain, breathing difficulty, and running nose.
- What are the instructions for storage and disposal Atova 20 mg Tablet?: Store at room temperature, away from heat and direct light, keep away from children and pets.
- Is Atova 20 mg Tablet used for lowering cholesterol?: Yes, it is used to lower cholesterol and triglycerides in the blood.