Keto-A 50 mg (Tablet (Enteric Coated))

Unit Price: ৳ 3.52 (5 x 10: ৳ 176.00)

Strip Price: ৳ 35.20

Medicine Details

Category	Details
Generic	Ketoprofen oral injection
Company	Acme laboratories ltd
Also available as	Keto a 100 mg tablet Keto a 100 mg injection Keto a 100 mg suppository

Relief of rheumatoid arthritis
Treatment of degenerative joint diseases
Alleviation of musculoskeletal and joint disorders such as tendinitis and sprain
Managing pain from dental issues, headache, and primary dysmenorrhea

Recommended starting dose of 150 to 300 mg/day in 3 divided doses for anti-inflammatory purposes
Usual recommended dose of 25 to 50 mg, every 6 to 8 hours for pain management
Maximum daily dose of 300 mg

Not recommended drug associations with other NSAIDs and high dose salicylates
Increased risk of bleeding with anticoagulants
Increased risk of elevation of lithium plasma levels with lithium
Increased risk of haematologic toxicity of methotrexate at doses greater than 15mg/week
Risk of hyperkalemia with certain medicinal products and therapeutic categories
Increased risk of gastrointestinal ulceration or bleeding with corticosteroids
Patients taking diuretics at greater risk of developing renal failure
Possible deterioration of renal function with compromised renal function and co-administration of ACE inhibitors or Angiotensin II Antagonists
Increased risk for severe complications with concomitant administration of nicorandil and NSAIDs
Potential pharmacokinetic interaction between ketoprofen and digoxin
Increased risk of nephrotoxicity with cyclosporin and tacrolimus
Monitoring of full blood count during combination treatment with methotrexate at doses lower than 15mg/week
More frequent clinical monitoring and monitoring of bleeding time required with pentoxifylline
Increased risk of renal failure with concomitant administration of tenofovir disoproxil fumarate and NSAIDs
Risk of decreased antihypertensive potency with antihypertensive agents
Increased risk of bleeding with thrombolytics and increased risk of gastrointestinal bleeding with selective serotonin reuptake inhibitors (SSRIs)

History of hypersensitivity reactions to ketoprofen, ASA or other NSAIDs
Severe heart failure
Active or history of peptic ulcer/hemorrhage
History of gastrointestinal bleeding or perforation related to previous NSAIDs therapy
Severe hepatic insufficiency
Severe renal insufficiency
Third trimester of pregnancy
Rectitis or history of proctorrhagia (rectal administration)

Rare: haemorrhagic anaemia
Unknown: agranulocytosis, thrombocytopenia, bone marrow failure, hemolytic anemia, leucopenia
Unknown: anaphylactic reactions (including shock)
Unknown: depression, hallucinations, confusion, altered mood
Uncommon: headache, dizziness, somnolence
Rare: paraesthesia
Unknown: aseptic meningitis, convulsions, dysgeusia, vertigo
Rare: vision blurred
Rare: tinnitus
Unknown: exacerbation of heart failure, atrial fibrillation
Unknown: hypertension, vasodilatation, vasculitis
Rare: asthma
Unknown: bronchospasm (particularly in patients with known hypersensitivity to ASA and other NSAIDs)
Common: dyspepsia, nausea, abdominal pain, vomiting
Uncommon: constipation, diarrhea, flatulence, gastritis
Rare: stomatitis, peptic ulcer
Unknown: exacerbation of colitis and Crohn’s disease, gastrointestinal haemorrhage and perforation, pancreatitis
Rare: hepatitis, transaminases increased
Uncommon: rash, pruritus
Unknown: photosensitivity reaction, alopecia, urticaria, angioedema, bullous eruption including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis
Unknown: renal failure acute, tubulointerstitial nephritis, nephritic syndrome, abnormal renal function tests
Uncommon: edema
Unknown: hyponatremia, hyperkalemia
Rare: weight increased

Careful administration to patients with a history of gastrointestinal disease
Renal function monitoring for patients with heart failure, cirrhosis, nephrosis, diuretic therapy, or chronic renal impairment
Caution required in patients with a history of hypertension and/or congestive heart failure
Monitoring for atrial fibrillation
Potential occurrence of hyperkalemia
Masking of signs of infection progression such as fever
Periodic evaluation of liver function tests in patients with abnormal liver function or a history of liver disease
Discontinuation if visual disturbances occur
Impairment of female fertility
Consideration of withdrawal in women attempting to conceive or undergoing infertility investigation

Reduced initial dosage and minimal effective dose for the elderly
Careful monitoring and minimal effective daily dosage for patients with hepatic impairment
Reduced initial dosage and minimal effective dose for patients with renal impairment

Reported cases of benign symptoms with overdose
No specific antidotes
Recommendation of gastric lavage and symptomatic treatment for massive overdosages
Potential usefulness of hemodialysis in the presence of renal failure