Keto-A 100 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.53 (5 x 10: ৳ 276.50)

Strip Price: ৳ 55.30

Medicine Details

Category	Details
Generic	Ketoprofen oral injection
Company	Acme laboratories ltd
Also available as	Keto a 50 mg tablet Keto a 100 mg injection Keto a 100 mg suppository

Symptomatic treatment of rheumatoid arthritis
Management of degenerative joint diseases
Relief of musculoskeletal and joint disorders such as tendinitis and sprain
Treatment of pain, including dental pain, headache, and primary dysmenorrhea
Non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic actions
Rapid and complete absorption from the GI tract
Approximately 99% bound to plasma protein, mainly albumin
Excretion in urine (50-90%) and faeces (1-8%) within 1-5 days
Peak concentration of approximately 10 mg/L reached at about 0.5-0.75 hour after 100 mg IM injection
Elimination half-life of approximately 1.88 hours
Oral forms should be taken with fluids, preferably with food
Contraindicated in patients with hypersensitivity reactions, severe heart failure, peptic ulcer/hemorrhage, severe hepatic or renal insufficiency, and in the third trimester of pregnancy
Not recommended during the first and second trimesters of pregnancy and in nursing mothers
Caution required in patients with a history of gastrointestinal disease, renal impairment, hypertension, congestive heart failure, and infectious disease
Discontinue treatment if visual disturbances occur
Reduced initial dosage and careful monitoring in elderly patients, those with hepatic or renal impairment
Store below 30°C, protect from light, and do not use after the expiry date

Starting dose: 150-300 mg/day in 3 divided doses for anti-inflammatory purposes
Recommended maintenance dosage: 100-200 mg/day
Usual dose for pain and primary dysmenorrhea: 25-50 mg every 6-8 hours, not to exceed 300 mg/day

Increased risk of gastrointestinal ulceration and bleeding with other NSAIDs and high-dose salicylates
Increased risk of bleeding with anticoagulants like heparin, warfarin, and platelet aggregation inhibitors
Coadministration with lithium may elevate lithium plasma levels
Risk of haematologic toxicity of methotrexate, particularly at high doses
Potential for drug interactions leading to hyperkalemia

Rare: Haemorrhagic anemia, blurred vision, tinnitus
Uncommon: Headache, dizziness, somnolence, dyspepsia, nausea, abdominal pain
Unknown: Agranulocytosis, thrombocytopenia, depression, hallucinations, hypertension, exacerbation of heart failure, asthma, hepatitis, rash
Potential for renal failure and impaired female fertility

Use with caution in patients with a history of gastrointestinal disease, heart failure, and chronic renal impairment
Monitor renal function in patients at risk of fluid retention and oedema
Caution required in patients with abnormal liver function tests or visual disturbances
Avoid use in women attempting to conceive
Minimize dosage in elderly, hepatically or renally impaired patients
Monitor for symptoms of overdose, especially in cases of massive overdosages

Elderly: Reduce initial dosage and maintain on minimal effective dose
Hepatic impairment: Monitor carefully and maintain at minimal effective daily dosage
Renal impairment: Reduce initial dosage and maintain on minimal effective dose

Symptoms include lethargy, drowsiness, nausea, vomiting, and epigastric pain
No specific antidotes to ketoprofen overdosages
Institute symptomatic and supportive treatment, and consider hemodialysis in cases of renal failure
Gastric lavage recommended for massive overdosages