Keto-A 100 mg (Suppository)

Unit Price: ৳ 12.09 (2 x 5: ৳ 120.90)

Medicine Details

Category Details
Generic Ketoprofen oral injection
Company Acme laboratories ltd
Also available as
Keto a 50 mg tablet Keto a 100 mg tablet Keto a 100 mg injection

Indications

  • Rheumatoid arthritis
  • Degenerative joint diseases
  • Musculoskeletal and joint disorders
  • Pain relief for dental pain
  • Pain relief for headache
  • Pain relief for dysmenorrhea

Pharmacology

  • Non-steroidal anti-inflammatory drug (NSAID)
  • Analgesic
  • Antipyretic
  • Inhibition of prostaglandin synthesis
  • Stabilizes lysosomal membranes
  • Inhibits leukotriene synthesis
  • Antibradykinin activity

Dosage

  • Recommended starting dose of 150-300 mg/day
  • Maintenance dosage of 100-200 mg/day
  • Usual recommended dose for pain management: 25-50 mg every 6-8 hours
  • Maximum daily dose of 300 mg

Administration

  • Oral forms to be taken with fluids
  • Preferably with food

Interactions

  • Not recommended with other NSAIDs
  • Increased risk of gastrointestinal ulceration and bleeding with anticoagulants
  • Coadministration precautions for lithium
  • Increased risk of haematologic toxicity with high dose methotrexate
  • Risk of hyperkalemia with certain medicinal products
  • Increased risk of gastrointestinal ulceration or bleeding with corticosteroids
  • Patients taking diuretics at greater risk of renal failure
  • Possible acute renal failure with ACE inhibitors and Angiotensin II Antagonists

Contraindications

  • Hypersensitivity reactions to ketoprofen, ASA, or other NSAIDs
  • Severe heart failure
  • Active or history of peptic ulcer/hemorrhage
  • Severe hepatic insufficiency
  • Severe renal insufficiency
  • Third trimester of pregnancy
  • Rectitis or history of proctorrhagia

Side Effects

  • Haemorrhagic anaemia
  • Anaphylactic reactions
  • Headache
  • Vision blurred
  • Asthma
  • Hepatitis
  • Rash
  • Renal failure acute

Pregnancy & Lactation

  • Avoid use during first and second trimester of pregnancy
  • Contraindicated in last trimester of pregnancy
  • Not recommended in nursing mothers

Precautions & Warnings

  • Caution in patients with gastrointestinal disease
  • Careful monitoring of renal function
  • Caution in patients with abnormal liver function tests
  • Consider withdrawal in women attempting to conceive

Use in Special Populations

  • Reduced initial dosage for Elderly
  • Careful monitoring for Hepatic impairment
  • Reduced initial dosage for Renal impairment

Overdose Effects

  • Symptoms include lethargy, drowsiness, nausea, vomiting, and epigastric pain
  • No specific antidotes available

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Protect from light
  • Store below 30°C
  • Do not use after expiry date
  • Keep out of reach of children
  • Dispensed only on prescription of a registered physician

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