Kop SR 100 mg (Capsule (Sustained Release))

Unit Price: ৳ 11.03 (5 x 10: ৳ 551.50)

Strip Price: ৳ 110.30

Medicine Details

Category	Details
Generic	Ketoprofen oral injection
Company	Square pharmaceuticals plc

Indications

Rheumatoid arthritis
Degenerative joint diseases
Musculoskeletal and joint disorders
Pain relief for dental pain
Pain relief for headache
Pain relief for primary dysmenorrhea

Pharmacology

Anti-inflammatory properties
Analgesic actions
Antipyretic actions
Inhibition of prostaglandin synthesis
Stabilization of lysosomal membranes
Inhibition of leukotriene synthesis

Dosage

Recommended starting dose of 150 to 300 mg/day
Maintenance dosage of 100 to 200 mg/day
Twice daily dose regimen for maintenance
Maximum daily dose of 300 mg
Usual recommended dose of 25 to 50 mg for pain management
Every 6 to 8 hours dosing for pain relief

Administration

Oral administration with fluids
Preferably taken with food

Interactions

Not recommended drug associations
Increased risk of gastrointestinal ulceration and bleeding with other NSAIDs
Increased risk of bleeding with anticoagulants
Heparin interaction
Vitamin K antagonists interaction
Platelet aggregation inhibitors interaction
Thrombin inhibitors interaction
Direct factor Xa inhibitors interaction
Risk of elevation of lithium plasma levels with lithium
Increased risk of haematologic toxicity of methotrexate
Drug associations requiring precautions for use
Drug associations to be taken into account
Potential interactions with various therapeutic categories

Contraindications

Contraindicated in patients with history of hypersensitivity reactions
Severe heart failure contraindication
Active or history of peptic ulcer/hemorrhage contraindication
History of gastrointestinal bleeding or perforation contraindication
Severe hepatic insufficiency contraindication
Severe renal insufficiency contraindication
Third trimester of pregnancy contraindication
Rectitis or history of proctorrhagia (rectal administration) contraindication

Side Effects

Various blood and lymphatic system disorders
Potential immune system disorders
Nervous system disorders
Possible eye disorders
Ear and labyrinth disorders
Cardiac disorders
Vascular disorders
Respiratory, thoracic and mediastinal disorders
Gastrointestinal disorders
Hepatobiliary disorders
Skin and subcutaneous disorders
Renal and urinary disorders
General disorders and administration site conditions
Metabolism and nutritional disorders
Investigation-related side effects

Pregnancy & Lactation

Avoid use during first and second trimester
Contraindicated during third trimester
Not recommended in nursing mothers

Precautions & Warnings

Given with care to patients with a history of gastrointestinal disease
Renal function monitoring required
Caution in patients with hypertension and/or congestive heart failure
Increased risk of atrial fibrillation
Potential for hyperkalemia
Masking of infection progression signs
Monitoring of liver function tests
Possibility of visual disturbances
Impairment of female fertility
Considerations for patients with abnormal liver function tests
Caution in patients with infectious diseases

Use in Special Populations

Special considerations for elderly patients
Care for patients with hepatic impairment
Minimal effective daily dosage for renal impairment patients

Overdose Effects

Reported overdose cases up to 2.5 g of ketoprofen
Symptoms include lethargy, drowsiness, nausea, vomiting, and epigastric pain
No specific antidotes available
Recommendations for symptomatic and supportive treatment
Possibility of renal failure and need for hemodialysis

Therapeutic Class

Drugs for Osteoarthritis
Drugs used for Rheumatoid Arthritis
Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Protection from light
Storage below 30°C
Expiry date adherence
Keep out of reach of children
Dispensing only on the prescription of a registered physician

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