Atovin 10 mg (Tablet)

Unit Price: ৳ 10.03 (1 x 10: ৳ 100.30)
Strip Price: ৳ 100.30

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Alco pharma ltd
Also available as
Atovin 20 mg tablet

Product title

  • Atovin 10 mg Tablet

Therapeutic class

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Pharmacology

  • Selective inhibitor of HMG-CoA reductase
  • Lowers plasma cholesterol and lipoprotein levels
  • Inhibits HMG-CoA reductase and cholesterol synthesis in the liver
  • Increases the number of hepatic LDL receptors for enhanced uptake and catabolism of LDL

Indications

  • Reduces elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels
  • Reduces total cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolaemia
  • Reduces elevated cholesterol and triglycerides in patient with mixed dyslipidemia
  • Treats patients with elevated serum triglyceride levels in hypertriglyceridaemia
  • Treats patients with dysbetalipoproteinaemia
  • Reduces cardiac ischaemic events in patients with coronary artery disease with elevated LDL-cholesterol level
  • Reduces total and LDL-cholesterol concentrations in patients with hypercholesterolemia associated with diabetes mellitus or renal transplantation

Contraindications

  • Hypersensitivity to any component of this medication
  • Active liver disease or unexplained persistent elevations of serum transaminases
  • History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Dosage administration

  • Adults: Usually 10 mg once daily; may be increased to max. 80 mg once daily if necessary
  • Children (10-18 years): Initially 10 mg once daily, increased if necessary to usual max. 20 mg once daily

Interaction

  • Increased risk of myopathy with concurrent administration of cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals
  • Antacid coadministration decreases plasma concentrations of atorvastatin
  • Colestipol coadministration decreases plasma concentrations but increases LDL-C reduction
  • Erythromycin coadministration increases plasma concentrations of atorvastatin
  • Oral contraceptives coadministration increases AUC values for norethindrone and ethinyl estradiol
  • Warfarin coadministration has no clinically significant effect on prothrombin time

Side effects

  • Most frequent side effects: constipation, flatulence, dyspepsia, abdominal pain. Other side effects: infection, headache, back pain, rash, asthenia, arthralgia, myalgia

Pregnancy lactation

  • Atorvastatin is contraindicated during pregnancy
  • Not known whether atorvastatin or its metabolites are excreted in human milk
  • Maternal treatment may reduce fetal levels of mevalonate
  • Atorvastatin should not be used in women who are pregnant, trying to become pregnant or breastfeeding

Precautions warnings

  • Liver function tests should be performed before initiation of treatment and periodically thereafter
  • Atovin should be used with caution in patients who consume substantial quantities of alcohol or have a history of liver disease
  • Therapy should be discontinued if markedly elevated CPK levels occur or myopathy is diagnosed or suspected

Special populations

  • Plasma concentrations of Atovin are higher in healthy elderly subjects than in young adults
  • No clinically significant difference in LDL-C reduction with Atovin between men and women
  • Renal disease has no influence on the plasma concentrations or LDL-C reduction of Atovin
  • Hemodialysis is not expected to significantly enhance clearance of Atovin
  • Plasma concentrations of Atovin are markedly increased in patients with chronic alcoholic liver disease

Overdose effects

  • Specific treatment is not available for atorvastatin overdose
  • Patient should be treated symptomatically and supportive measures instituted, as required
  • Liver function tests should be performed and serum CK levels should be monitored
  • Hemodialysis is not expected to significantly enhance clearance of atorvastatin

Storage conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical structure

  • Molecular Formula: C33H35FN2O5
  • Chemical Structure: Image of chemical structure

Common questions

  • What is Atovin 10 mg Tablet?
  • How should I take Atovin 10 mg Tablet?
  • What are the uses of Atovin 10 mg Tablet?
  • What are the Side Effects of Atovin 10 mg Tablet?
  • What are the instructions for storage and disposal Atovin 10 mg Tablet?
  • Is Atovin 10 mg Tablet used for lowering cholesterol?
  • Will taking Atovin 10 mg Tablet increase my risk of diabetes?
  • For how long do I need to take Atovin 10 mg Tablet? Is it safe for long-term use?
  • Does Atovin 10 mg Tablet cause weight loss?
  • Can I stop taking Atovin 10 mg Tablet?
  • Does Atovin 10 mg Tablet cause memory loss?
  • Does Atovin 10 mg Tablet make you tired?
  • Can Atovin 10 mg Tablet be prescribed to children?
  • Is Atovin 10 mg Tablet a blood thinner?
  • Quick Tips

Absorption

Rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours

Distribution

Mean volume of distribution is approximately 381 liters; 98% bound to plasma proteins

Metabolism

Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products

Excretion

Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism; mean plasma elimination half-life is approximately 14 hours

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