Atrovast 10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Nuvista pharma ltd |
| Also available as |
Title
Atrovast 10 mg Tablet
Categories
- Medicine
- Cholesterol management
- Cardiovascular health
Description
Atrovast is indicated to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B), and triglycerides levels in various diseases such as heterozygous and homozygous familial hypercholesterolaemia, mixed dyslipidemia, hypertriglyceridaemia, dysbetalipoproteinaemia, coronary artery disease, hypercholesterolemia associated with diabetes mellitus or renal transplantation. It works as a selective inhibitor of HMG-CoA reductase, lowering plasma cholesterol and lipoprotein levels by inhibiting cholesterol synthesis and increasing hepatic LDL receptors. The recommended dosage ranges from 10 to 80 mg once daily and should be administered with caution in patients with liver disease. Atrovast has potential interactions with several drugs including cyclosporine, fibric acid derivatives, niacin, erythromycin, and oral contraceptives. It is contraindicated in pregnancy, lactation, active liver disease, and hypersensitivity to any component of the medication. Common side effects include constipation, flatulence, dyspepsia, abdominal pain, infection, headache, back pain, rash, asthenia, arthralgia, and myalgia. It should be stored in a dry place away from light and heat and kept out of the reach of children.
Dimensions
- N/A
Color options
- N/A
Functions
- Lowers total cholesterol levels
- Reduces LDL cholesterol levels
- Lowers apolipoprotein B (Apo-B) levels
- Reduces triglycerides levels
- Prevents cardiac ischaemic events
- Enhances hepatic LDL receptors' activity
Materials
- N/A
Technical specifications
- Absorption: Rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours.
- Distribution: Mean volume of distribution is approximately 381 liters; 98% bound to plasma proteins.
- Metabolism: Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products.
- Excretion: Primarily eliminated in bile following hepatic and/or extra-hepatic metabolism.
Design elements
- N/A
Usability features
- Dosage & Administration:
- Usually 10 mg once daily; may be increased to max. 80 mg once daily depending on the condition being treated.
- Interaction:
- Potential interactions with antacid, colestipol, digoxin, erythromycin, oral contraceptives, and warfarin.
- Contraindications:
- Contraindicated in active liver disease, hypersensitivity to any component, and history of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors.
- Side Effects:
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
- Pregnancy & Lactation:
- Contraindicated during pregnancy and breastfeeding; may reduce fetal levels of mevalonate which is a precursor of cholesterol biosynthesis.
- Precautions & Warnings:
- Liver function tests should be performed before initiation of treatment and periodically thereafter.
Additional attributes
- Recommended starting dose is 10 or 20 mg once daily
- Plasma concentrations are higher in elderly patients
- No clinically significant difference in LDL-C reduction between men and women
- Renal disease has no influence on the plasma concentrations
- No specific treatment available for atorvastatin overdose
- Therapeutic class: Other Anti-anginal & Anti-ischaemic drugs, Statins
- Storage conditions: Keep in a dry place away from light and heat; keep out of the reach of children