Atrovast 20 mg (Tablet)
Unit Price: ৳ 18.05 (2 x 10: ৳ 361.00)
Strip Price: ৳ 180.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Nuvista pharma ltd |
| Also available as |
Title
- Atrovast 20 mg Tablet
Categories
- Cardiovascular Medicine
- Cholesterol Lowering Medications
- Statins
Description
- Atorvastatin is a selective inhibitor of HMG-CoA reductase.
- It is used to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B, and triglycerides levels.
- It is indicated for various diseases including familial hypercholesterolemia, mixed dyslipidemia, and hypertriglyceridemia.
- It is also used for the treatment of patients with dysbetalipoproteinaemia and to reduce cardiac ischaemic events.
- Atorvastatin is rapidly absorbed after oral administration, with maximum plasma concentrations occurring within 1 to 2 hours.
Dosage
- Adults: Usually 10 mg once daily; may be increased to max. 80 mg once daily.
- Children (10-18 years): Usual max. 20 mg once daily.
- For familial hypercholesterolaemia: Initially 10 mg daily, increased at intervals to max. 80 mg once daily.
Absorption
- Atorvastatin is rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours.
Distribution
- Mean volume of distribution of Atorvastatin is approximately 381 liters.
Metabolism
- Atorvastatin is extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products.
Excretion
- Atorvastatin and its metabolites are eliminated primarily in bile following hepatic and/or extra-hepatic metabolism.
Contraindications
- Hypersensitivity to any component of this medication
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pharmacology
- Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver.
Interaction
- Increased risk of myopathy with concurrent administration of cyclosporine, fibric acid derivatives, niacin, erythromycin, and azole antifungals
- Coadministration with antacid suspension or colestipol may alter plasma concentrations of atorvastatin.
Pregnancy & Lactation
- Contraindicated during pregnancy
- Not known whether atorvastatin or its metabolites are excreted in human milk
Precautions & Warnings
- Liver function tests should be performed before the initiation of treatment and periodically thereafter
- Use with caution in patients who consume substantial quantities of alcohol or have a history of liver disease
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C33H35FN2O5
Use in Special Populations
- Plasma concentrations of Atrovast are higher in healthy elderly subjects than in young adults
- No clinically significant difference in LDL-C reduction with Atrovast between men and women
- Renal disease has no influence on the plasma concentrations or LDL-C reduction of Atrovast