Bpxen 250 mg (Tablet)
Unit Price: ৳ 4.00 (50's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Naproxen sodium |
| Company | Bristol pharmaceuticals ltd |
| Also available as |
Indications
- relief of sign and symptoms of rheumatoid arthritis
- relief of sign and symptoms of osteoarthritis
- relief of sign and symptoms of ankylosing spondylitis
- relief of sign and symptoms of juvenile arthritis
- relief of sign and symptoms of tendonitis
- relief of sign and symptoms of bursitis
- relief of sign and symptoms of acute gout
- management of primary dysmenorrhea & pain
Pharmacology
- COX-1 and COX-2 enzyme blocking
- decreased prostaglandin synthesis
- antipyretic properties
- analgesic properties
- anti-inflammatory properties
- gastrointestinal upset linked to COX-1 enzyme
- renal toxicities linked to COX-1 enzyme
Dosage & Administration
- taken with water preferably after meals
- dosage varies for different indications
- dosage for adults with rheumatoid arthritis/ osteoarthritis/ ankylosing spondylitis
- dosage for adults with acute gout
- dosage for adults with dysmenorrhoea
- dosage for other indications like analgesia and acute musculoskeletal disorders
- dosage for children with juvenile rheumatoid arthritis
- dosage for children via suspension
- dosage for naproxen gel application
Interaction
- diminish the antihypertensive effect of ACE inhibitors
- delay the absorption of Bpxen by antacids & Sucralfate
- increase adverse effects when used with Aspirin
- reduce the natriuretic effect of Diuretics
- enhance the toxicity of Methotrexate
- increase the risk of GI bleeding when used with Warfarin and Selective Serotonin Reuptake Inhibitors (SSRI)
Contraindications
- hypersensitivity to Naproxen
- asthma or allergic-type reactions after taking aspirin or other NSAIDs
- perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
Side Effects
- Gastrointestinal - Heartburn
- Gastrointestinal - abdominal pain
- Gastrointestinal - nausea
- Gastrointestinal - diarrhea
- Gastrointestinal - dyspepsia
- Central Nervous System - Headache
- Central Nervous System - vertigo
- Central Nervous System - drowsiness
- Dermatological - Pruritus (itching)
- Dermatological - purpura
- Cardiovascular - Edema
- Cardiovascular - palpitation
- Others - Visual disturbances
- Others - hearing disturbances
Pregnancy & Lactation
- adverse effects on fetus
- delay in parturition in animals
- premature closure of the ductus arteriosus in infants born to mothers taking Naproxen
- excreted in small amounts in the breast milk
- considered by some authorities to be too small to be harmful to a breast-fed infant
Precautions & Warnings
- renal effects
- acute interstitial nephritis
- hematuria
- proteinuria
- nephrotic syndrome
- elimination primarily by the kidneys
- use with caution in patients with impaired renal function
- monitoring of serum creatinine and/or creatinine clearance
- use with caution in patients with significantly impaired renal function
- accumulation of naproxen metabolites in patients with creatinine clearance of less than 20ml/min
- few reports of moderate to severe jaundice attributed to Bpxen
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Keep below 30°C temperature
- protected from light & moisture
- Keep out of the reach of children