Napoxen 500 mg (Tablet)

Unit Price: ৳ 7.00 (30's pack: ৳ 210.00)

Medicine Details

Category Details
Generic Naproxen sodium
Company Edruc limited
Also available as

Title

  • Napoxen

Categories

  • Pain Relief
  • NSAID
  • Arthritis Medication

Description

  • Napoxen is indicated for the relief of sign and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis, acute gout, dysmenorrhea, and pain.
  • It is also indicated for the management of primary dysmenorrhea & pain.
  • Naproxen exerts its clinical effects by blocking COX-1 and COX-2 enzymes leading to decreased prostaglandin synthesis.
  • Naproxen oral preparations should be taken with water preferably after meals.
  • ACE inhibitors diminish the antihypertensive effect of ACE inhibitors.
  • Naproxen is contraindicated in patients with known hypersensitivity to Naproxen.
  • Most frequently reported side effects include gastrointestinal, central nervous system, dermatological, cardiovascular, and other effects.
  • Naproxen causes a delay in parturition in animals and has been associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking Naproxen.
  • As with other non-steroidal anti-inflammatory drugs, long-term administration of naproxen to animal has resulted in renal papillary necrosis and other abnormal renal pathology.
  • Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Indications

  • Rheumatoid Arthritis
  • Osteoarthritis
  • Ankylosing Spondylitis
  • Juvenile Arthritis
  • Tendonitis
  • Bursitis
  • Acute Gout
  • Primary Dysmenorrhea
  • Pain

Mode of Action

  • Blocks COX-1 and COX-2 enzymes
  • Decreases prostaglandin synthesis

Dosage & Administration

  • Naproxen Enteric Coated Tablet for adults: 500-1000 mg per day taken in two divided doses at 12-hour intervals.
  • For acute gout: 750 mg should be given initially, then 250 mg every 8 hours until the attack has passed.
  • Naproxen Suspension for juvenile rheumatoid arthritis: The usual dose for children over 2 years is 10 mg/kg/day given as two divided doses at 12-hour intervals.
  • Naproxen Gel is to be applied 2-6 times a day as required and is not recommended for use in children.

Interaction

  • ACE inhibitors diminish the antihypertensive effect of ACE inhibitors.
  • Antacids & Sucralfate delay the absorption of Napoxen.
  • Aspirin increases adverse effects.
  • Diuretics reduce the natriuretic effect of Furosemide and Thiazides.
  • Methotrexate enhances the toxicity of Methotrexate.
  • Warfarin increases the risk of GI bleeding.
  • Selective Serotonin Reuptake Inhibitors (SSRI) increase the risk of GI bleeding.

Contraindications

  • Hypersensitivity to Naproxen
  • Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
  • Perioperative pain in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Gastrointestinal
  • Central Nervous System
  • Dermatological
  • Cardiovascular
  • Others

Pregnancy & Lactation

  • Adverse effect on the fetus
  • Causes a delay in parturition in animals
  • Associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants

Precautions & Warnings

  • Renal effects
  • Hepatic effects

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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