Naprox 250 mg (Tablet)
Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Naproxen sodium |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- rheumatoid arthritis
- osteoarthritis
- ankylosing spondylitis
- juvenile arthritis
- tendonitis
- bursitis
- acute gout
- primary dysmenorrhea
- pain
Pharmacology
- Block COX-1 and COX-2 enzymes
- Decrease prostaglandin synthesis
- Offer antipyretic, analgesic, and anti-inflammatory properties
- Linked to gastrointestinal upset and renal toxicities
Dosage & Administration
- Taken with water after meals
- Adult dosage for different indications
- Children's dosage for specific conditions
- Naproxen Gel application frequency
Interaction
- Diminish ACE inhibitors' antihypertensive effect
- Delay absorption with antacids & Sucralfate
- Increase adverse effects when taken with Aspirin
- Reduce natriuretic effect of Diuretics
- Enhance Methotrexate toxicity
- Increase the risk of GI bleeding with Warfarin
- Increase the risk of GI bleeding with Selective Serotonin Reuptake Inhibitors (SSRI)
Contraindications
- Known hypersensitivity to Naproxen
- Experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
Side Effects
- Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia
- Central Nervous System: Headache, vertigo, drowsiness
- Dermatological: Pruritus (itching), purpura
- Cardiovascular: Edema, palpitation
- Others: Visual disturbances, hearing disturbances
Pregnancy & Lactation
- Adverse effect on the fetus through pharmacological properties
- Causes a delay in parturition and associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking Naproxen
- Requires careful balancing of benefits to the mother against possible risks to the fetus
- Excreted in small amounts in breast milk for nursing mothers
- Amount distributed into breast milk is considered by some authorities to be too small to be harmful to a breast-fed infant
Precautions & Warnings
- Long-term administration resulted in renal papillary necrosis and other abnormal renal pathology in animals
- Reports of acute interstitial nephritis, hematuria, proteinuria, and occasionally nephrotic syndrome associated with Naprox-containing products
- Eliminated primarily by the kidneys
- Use with caution in patients with significantly impaired renal function
- Caution if given to patients with creatinine clearance of less than 20ml/min
- Reports of moderate to severe jaundice attributed to Naprox
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children