Napryn 500 mg (Tablet)
Unit Price: ৳ 11.00 (5 x 10: ৳ 550.00)
Strip Price: ৳ 110.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Naproxen sodium |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Title
- Napryn
Categories
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
- Pain Management
- Arthritis Medication
Indications
- Relief of rheumatoid arthritis
- Relief of osteoarthritis
- Relief of ankylosing spondylitis
- Relief of juvenile arthritis
- Relief of tendonitis
- Relief of bursitis
- Relief of acute gout
- Management of primary dysmenorrhea & pain
Pharmacology
- Blocks COX-1 and COX-2 enzymes
- Decreases prostaglandin synthesis
- Offers antipyretic, analgesic, and anti-inflammatory properties
- Linked to gastrointestinal upset and renal toxicities
Dosage & Administration
- Taken with water, preferably after meals
- For adults: 500-1000 mg per day in two divided doses at 12-hour intervals
- For acute gout: 750 mg initially, then 250 mg every 8 hours
- For dysmenorrhoea: 500 mg initially, followed by 250 mg at 6-8 hour intervals for up to 5 days
- For children over 2 years: 10 mg/kg/day in two divided doses at 12-hour intervals
- Naproxen Gel: Applied 2-6 times a day as required
Interaction
- Diminishes the antihypertensive effect of ACE inhibitors
- Delays the absorption of Napryn
- Increases adverse effects when taken with aspirin
- Reduces the natriuretic effect of diuretics
- Enhances the toxicity of Methotrexate
- Increases the risk of GI bleeding with Warfarin and Selective Serotonin Reuptake Inhibitors (SSRI)
Contraindications
- Patients with known hypersensitivity to Naproxen
- Patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
Side Effects
- Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia
- Central Nervous System: Headache, vertigo, drowsiness
- Dermatological: Pruritus (itching), purpura
- Cardiovascular: Edema, palpitation
- Others: Visual disturbances, hearing disturbances
Pregnancy & Lactation
- Adverse effects on the fetus
- Causes a delay in parturition in animals
- Associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking Naproxen
- Excreted in small amounts in breast milk
- Considered by some authorities to be too small to be harmful to a breastfed infant
Precautions & Warnings
- Long-term administration may result in renal papillary necrosis and other abnormal renal pathology
- Reports of acute interstitial nephritis, hematuria, proteinuria, and occasionally nephrotic syndrome
- Use with caution in patients with significantly impaired renal function
- Monitoring of serum creatinine and/or creatinine clearance advised
- Few reports of moderate to severe jaundice attributed to Napryn
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- NSAIDs
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children