Nuprafen 500 mg (Tablet)

Unit Price: ৳ 7.85 (5 x 10: ৳ 392.50)
Strip Price: ৳ 78.50

Medicine Details

Category Details
Generic Naproxen sodium
Company Beximco pharmaceuticals ltd
Also available as

Indications

  • rheumatoid arthritis
  • osteoarthritis
  • ankylosing spondylitis
  • juvenile arthritis
  • tendonitis
  • bursitis
  • acute gout
  • dysmenorrhea

Pharmacology

  • blockage of COX-1 and COX-2 enzymes
  • decreased prostaglandin synthesis
  • antipyretic properties
  • analgesic properties
  • anti-inflammatory properties
  • unique functional differences of COX-1 and COX-2 enzymes

Dosage & Administration

  • oral preparation
  • taken with water
  • preference after meals
  • different dosages for different indications
  • enteric coated tablets
  • suspension for children
  • gel for topical application

Interactions

  • ACE inhibitors
  • Antacids & Sucralfate
  • Aspirin
  • Diuretics
  • Methotrexate
  • Warfarin
  • Selective Serotonin Reuptake Inhibitors (SSRI)

Contraindications

  • known hypersensitivity to Naproxen
  • asthma
  • urticaria
  • allergic-type reactions after taking aspirin or other NSAIDs
  • perioperative pain in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Gastrointestinal symptoms
  • Central Nervous System symptoms
  • Dermatological symptoms
  • Cardiovascular symptoms
  • Other reported symptoms

Pregnancy & Lactation

  • adverse effect on the fetus
  • delay in parturition
  • premature closure of the ductus arteriosus
  • severe pulmonary hypertension in infants
  • excretion in breast milk
  • balance of benefits and risks

Precautions & Warnings

  • Renal effects
  • Hepatic effects
  • renal pathology
  • acute interstitial nephritis
  • hematuria
  • proteinuria
  • nephrotic syndrome
  • accumulation of naproxen metabolites
  • serum creatinine monitoring
  • creatinine clearance monitoring
  • impaired renal function
  • hepatotoxicity

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • temperature below 30°C
  • protected from light
  • protected from moisture
  • keep out of the reach of children

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