Pairox 250 mg (Tablet)
Unit Price: ৳ 5.00 (50's pack: ৳ 250.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Naproxen sodium |
| Company | Asiatic laboratories ltd |
| Also available as |
Indications
- rheumatoid arthritis
- osteoarthritis
- ankylosing spondylitis
- juvenile arthritis
- tendonitis
- bursitis
- acute gout
- primary dysmenorrhea
- pain relief
Pharmacology
- blocks COX-1 and COX-2 enzymes
- decreases prostaglandin synthesis
- antipyretic
- analgesic
- anti-inflammatory
Dosage & Administration
- Oral intake with water
- Enteric Coated Tablet for adults and children
- Dosage for rheumatoid arthritis/osteoarthritis/ankylosing spondylitis
- Dosage for acute gout
- Dosage for dysmenorrhoea
- Dosage for other indications like analgesia and acute musculoskeletal disorders
- Naproxen Suspension dosage for juvenile rheumatoid arthritis
- Dosage guide for suspension based on weight
- Naproxen Gel application
Interaction
- ACE inhibitors diminish antihypertensive effect
- Antacids & Sucralfate delay absorption
- Aspirin increases adverse effects
- Diuretics reduce natriuretic effect of Furosemide and Thiazides
- Methotrexate enhances toxicity of Methotrexate
- Warfarin increases risk of GI bleeding
- Selective Serotonin Reuptake Inhibitors (SSRI) increase risk of GI bleeding
Contraindications
- Known hypersensitivity to Naproxen
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
Side Effects
- Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia
- Central Nervous System: Headache, vertigo, drowsiness
- Dermatological: Pruritus (itching), purpura
- Cardiovascular: Edema, palpitation
- Others: Visual disturbances, hearing disturbances
Pregnancy & Lactation
- Adverse effect on fetus
- Delay in parturition
- Premature closure of ductus arteriosus
- Severe pulmonary hypertension in infants
- Excretion in small amounts in breast milk
- Possible risks to the fetus
- Recommendations for nursing mothers
Precautions & Warnings
- Renal effects: renal papillary necrosis, abnormal renal pathology, acute interstitial nephritis, hematuria, proteinuria, nephrotic syndrome
- Monitoring of serum creatinine and/or creatinine clearance
- Caution with significantly impaired renal function
- Caution with creatinine clearance of less than 20ml/min
- Hepatic effects: moderate to severe jaundice
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children