Sonap 250 mg (Tablet)
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Naproxen sodium |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Relief of rheumatoid arthritis symptoms
- Relief of osteoarthritis symptoms
- Relief of ankylosing spondylitis symptoms
- Relief of juvenile arthritis symptoms
- Relief of tendonitis symptoms
- Relief of bursitis symptoms
- Relief of acute gout symptoms
- Management of primary dysmenorrhea & pain
Pharmacology
- Blocks COX-1 and COX-2 enzymes
- Decreased prostaglandin synthesis
- COX-2 enzyme mediates antipyretic, analgesic, and anti-inflammatory properties
- Undesired adverse effects linked to COX-1 enzyme
Dosage and administration
- Oral preparation should be taken with water
- Adult dosage for rheumatoid arthritis/osteoarthritis/ankylosing spondylitis
- Adult dosage for acute gout
- Adult dosage for dysmenorrhoea
- Adult dosage for other indications like analgesia and acute musculoskeletal disorders
- Children dosage for juvenile rheumatoid arthritis
- Application instructions for Naproxen Gel
Interaction
- Diminishes the antihypertensive effect of ACE inhibitors
- Delays the absorption of Sonap
- Increases adverse effects when combined with aspirin
- Reduces the natriuretic effect of diuretics
- Enhances the toxicity of Methotrexate
- Increases the risk of GI bleeding when combined with Warfarin
- Increases the risk of GI bleeding when combined with Selective Serotonin Reuptake Inhibitors
Contraindications
- Known hypersensitivity to Naproxen
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
Side effects
- Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia
- Central Nervous System: Headache, vertigo, drowsiness
- Dermatological: Pruritus (itching), purpura
- Cardiovascular: Edema, palpitation
- Others: Visual disturbances, hearing disturbances
Pregnancy and lactation
- Causes a delay in parturition in animals
- Associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking Naproxen
- Requires careful balancing of benefits to the mother against possible risks to the fetus
- Excreted in small amounts in breast milk
- Breastfeeding should be avoided during Naproxen therapy
Precautions and warnings
- Long-term administration may result in renal papillary necrosis and abnormal renal pathology
- Reports of acute interstitial nephritis, hematuria, proteinuria
- Eliminated primarily by the kidneys
- Use with caution in patients with significantly impaired renal function
- Monitoring of serum creatinine and/or creatinine clearance is advised
- Caution in patients with creatinine clearance of less than 20ml/min
- Reports of moderate to severe jaundice attributed to Sonap
Therapeutic class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children